Protein Alignment PCYT1A and Pcyt2

DIOPT Version :10

• Sequence 1: NP_005008.2
• Gene: PCYT1A / 5130
• HGNCID: 8754
• Length: 367
• Species: Homo sapiens
• Sequence 2: NP_647622.1
• Gene: Pcyt2 / 38180
• FlyBaseID: FBgn0035231
• Length: 381
• Species: Drosophila melanogaster
• Alignment Length: 285
• Identity: 165/285 - (57%)
• Similarity: 207/285 - (72%)
• Gaps: 16/285 - (5%)

Human    43 QPAPFSDE----IEVDFSKPYVRVTMEEASRGTPCERPVRVYADGIFDLFHSGHARALMQAKNLF 103
            ||||||.:    :|::......|:|...|..|....| ||||||||:||||.||||.||||||:|
  Fly    42 QPAPFSYDDKAMLELERCDYTQRITYHMARAGKTTRR-VRVYADGIYDLFHQGHARQLMQAKNVF 105

Human   104 PNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAH 168
            ||.|||||||:||||...||.||||..|||:||:|||||||:|.||||||..||:.||:||||||
  Fly   106 PNVYLIVGVCNDELTLRMKGRTVMNGFERYEAVRHCRYVDEIVPNAPWTLNEEFIEEHKIDFVAH 170

Human   169 DDIPYSSAGSDDVYKHIKEAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVS 233
            |||||.:.|.:|:|..:|..|||..|:||||:|||||:.|||:|||||.||||.|||:|||||||
  Fly   171 DDIPYGAGGVNDIYAPLKAKGMFVATERTEGVSTSDIVARIVKDYDVYVRRNLARGYSAKELNVS 235

Human   234 FINEKKYHLQERVDKVKKKVKDVEEKSKEFVQKVEEKSIDLIQKWEEKSREFIGSFLEMFGPEGA 298
            |::|||:.||.::|::|.:.|          :::.:..:|:|.||||||||||.:||.:||.| .
  Fly   236 FLSEKKFRLQNKMDELKTRGK----------RELTKVKVDIITKWEEKSREFIDAFLLLFGRE-R 289

Human   299 LKHMLKEGKGRMLQAISPKQSPSSS 323
            |.....|.|||::||:||..||:.|
  Fly   290 LNTFWNESKGRIIQALSPPGSPNGS 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PCYT1A	NP_005008.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33
		CCT	75..224	CDD:173925	106/148 (72%)
		Amphipathic. /evidence=ECO:0000255	228..287		26/58 (45%)
		Autoinhibitory (AI). /evidence=ECO:0000250|UniProtKB:P19836	272..293		14/20 (70%)
		Amphipathic. /evidence=ECO:0000255	298..315		7/16 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..367		6/11 (55%)
Pcyt2	NP_647622.1	PLN02413	75..334	CDD:215229	154/252 (61%)