DRSC/TRiP Functional Genomics Resources

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Protein Alignment PCYT1A and Pcyt1

DIOPT Version :10

Sequence 1:NP_005008.2 Gene:PCYT1A / 5130 HGNCID:8754 Length:367 Species:Homo sapiens
Sequence 2:NP_647621.1 Gene:Pcyt1 / 117353 FlyBaseID:FBgn0041342 Length:526 Species:Drosophila melanogaster


Alignment Length:324 Identity:173/324 - (53%)
Similarity:226/324 - (69%) Gaps:29/324 - (8%)


- Green bases have known domain annotations that are detailed below.


Human    14 RRKEAPGPNGATEEDGVP-SKVQRCAVG------LRQPAPFSDEIEV-------DFSKPYVRVTM 64
            :||..|....:.....|| |..|:...|      :.:|||:|.:.|.       |:::   |:|.
  Fly   133 KRKYVPQQQASPNHRVVPASTSQQFFSGASDFATICKPAPYSHDEEAMLERDRCDYTQ---RITY 194

Human    65 EEASRGTPCERPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNE 129
            :.|..|....| ||||||||:||||.||||.||||||:|||.|||||||:|||||..||.||||.
  Fly   195 QMARSGQTTRR-VRVYADGIYDLFHQGHARQLMQAKNIFPNVYLIVGVCNDELTHRMKGRTVMNG 258

Human   130 NERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKEAGMFAPT 194
            .|||:.|:|||||||:|:||||||:.||:|:::|||||||||||.:.|.||:|..:|..|||..|
  Fly   259 FERYEGVRHCRYVDEIVQNAPWTLSDEFIADNKIDFVAHDDIPYVTDGMDDIYAPLKARGMFVAT 323

Human   195 QRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYHLQERVDKVKKKVKDVEEK 259
            :||||:|||||:.|||:|||:|.||||.|||:||||||||::|||:.||.::|::|.:.|     
  Fly   324 ERTEGVSTSDIVARIVKDYDLYVRRNLARGYSAKELNVSFLSEKKFRLQNKMDELKSRGK----- 383

Human   260 SKEFVQKVEEKSIDLIQKWEEKSREFIGSFLEMFGPEGALKHMLKEGKGRMLQAISPKQSPSSS 323
                 :::.:..:|:|.||||||||||.:||.:||.|. |.|:..|.||::|||:||..|||.|
  Fly   384 -----RELSKVKVDIITKWEEKSREFIDTFLLLFGREN-LNHLWNESKGKLLQALSPPGSPSGS 441

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PCYT1ANP_005008.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33 5/19 (26%)
CCT 75..224 CDD:173925 105/148 (71%)
Amphipathic. /evidence=ECO:0000255 228..287 26/58 (45%)
Autoinhibitory (AI). /evidence=ECO:0000250|UniProtKB:P19836 272..293 14/20 (70%)
Amphipathic. /evidence=ECO:0000255 298..315 8/16 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 313..367 7/11 (64%)
Pcyt1NP_647621.1 CCT 204..353 CDD:173925 105/149 (70%)

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