Protein Alignment ECSIT and ECSIT

DIOPT Version :10

• Sequence 1: NP_057665.2
• Gene: ECSIT / 51295
• HGNCID: 29548
• Length: 431
• Species: Homo sapiens
• Sequence 2: NP_649602.2
• Gene: ECSIT / 40732
• FlyBaseID: FBgn0028436
• Length: 409
• Species: Drosophila melanogaster
• Alignment Length: 398
• Identity: 136/398 - (34%)
• Similarity: 220/398 - (55%)
• Gaps: 50/398 - (12%)

Human    56 PSPPEPRQRP-TKALVPFEDLFGQAPGGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMRE 119
            |:|....|:| ||.|....:.|..|.  :|.|.|:|..|:.|.|..|.:|.|::|||.||:.|.:
  Fly    37 PNPNPRAQKPGTKNLPALRNPFAAAQ--DRTKNSYLTMVEIFQERDVHRRNHVEFIYAALKNMAD 99

Human   120 YGVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETEFLLI 184
            :||||||.||..|:|:.||..|.|.|:.|..|:|||:||:|.|.:|||||:.||||:.|.|.:|:
  Fly   100 FGVERDLEVYKALINVMPKGKFIPTNMFQAEFMHYPKQQQCIIDLLEQMEDCGVMPDHEMEAMLL 164

Human   185 QIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLRHM-EPDLSARVTIYQVP 248
            .:|||:.:|:.|..|:..|.|:|.|::|:|:|..:|.|.:|:|...|..| ..||.:::|:::..
  Fly   165 NVFGRQGHPLRKYWRMMYWMPKFKNLSPWPLPDPVPDDTLEMAKLALERMCTVDLRSKITVFETS 229

Human   249 LPKDSTGAADPPQPHIVGIQSPDQQAALARHNPARPVFVEGPFSLWLRNKCVYYHILRAD----- 308
            ..||   |.|  ...||...||:|:..|..|:..:.:::||||.:||||:.:.|..||||
  Fly   230 ELKD---AID--DTWIVSGMSPEQEKLLREHSRQKALYIEGPFHIWLRNRRINYFTLRADADSEF 289

Human   309 LLPPEEREVEE--------------TPEEWNLYYPMQLDLEYVRSGWDNYEFDINEVEEGPVFAM 359
            |...:||:::|              .|...|       .|..:||        :::.::|.:.|:
  Fly   290 LSELDERQLDEDDVSHIEVPFFGRAPPRRHN-------QLGKLRS--------VHQQDDGTIMAI 339

Human   360 CMAGAHDQATMAKWIQGLQET-NPTLAQIPVVFRLAGSTRELQTSSAGLE---EPPLPEDHQEED 420
            |..|...:.::..||:.|:.. ||::.::||:||.   |.|:...:..:|   ..|...|:..:|
  Fly   340 CATGTSTKDSLLSWIRLLEANGNPSIGEVPVLFRF---TSEVPAKAEEIEGGASVPATSDNSSQD 401

Human   421 DNLQRQQQ 428
            :::..:|:
  Fly   402 EHISSRQK 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ECSIT	NP_057665.2	ECSIT	73..266	CDD:461857	81/193 (42%)
		PPR repeat	126..171	CDD:276811	24/44 (55%)
		ECSIT_C	269..393	CDD:464316	39/143 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..431		5/32 (16%)
ECSIT	NP_649602.2	ECSIT	55..242	CDD:461857	80/187 (43%)
		PPR repeat	68..100	CDD:276811	14/31 (45%)
		PPR repeat	106..151	CDD:276811	24/44 (55%)
		PPR repeat	157..181	CDD:276811	8/23 (35%)
		ECSIT_C	245..374	CDD:464316	41/148 (28%)