DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PCDH12 and ft

DIOPT Version :10

Sequence 1:XP_054208724.1 Gene:PCDH12 / 51294 HGNCID:8657 Length:1187 Species:Homo sapiens
Sequence 2:NP_477497.1 Gene:ft / 33627 FlyBaseID:FBgn0001075 Length:5147 Species:Drosophila melanogaster


Alignment Length:1543 Identity:327/1543 - (21%)
Similarity:511/1543 - (33%) Gaps:559/1543 - (36%)


- Green bases have known domain annotations that are detailed below.


Human    36 VSEEVPSGTVIGKLSQE------LGREERRRQAGAAFQVLQLPQALPIQVDSEEGLLSTGRRLDR 94
            |.|...:|||:..::.:      .||...|..:|......:|.:|..:.:....|:      |||
  Fly   396 VDENAVNGTVVAAVAVKDSDSGLNGRTSVRIVSGNELGHFRLEEAADLHIVRVNGV------LDR 454

Human    95 EQLCRQWDPCLVSFDVLATGDLALIHVEIQVLDINDHQPRFPKGEQELEISESASLRTRIPLDRA 159
            |:: .:::..:|:.|..........|:.|.|.|:|||:|.|.|.|....:||.|...:.:....|
  Fly   455 EEI-GKYNLTVVAMDQGTPARTTTAHLIIDVNDVNDH
EPVFEKSEYSAVLSELAPTGSFVASITA 518

Human   160 LDPDTGPNT-LHTYTLSPSE--HFALDVIVGPDETKHAELIVVK-ELDREIHSFFDLVLTAYDNG 220
            .|.|||.|. :|...||.:|  .|::|.:.|        |||.. .|||||....:|.::|.|.|
  Fly   519 TDEDTGVNAQVHYDILSGNELKWFSMDPLTG--------LIVTTGPLDREIRDTVELSISARDGG 575

Human   221 NPPKSGTSLVKVNVLDSNDNSPAFAESSLALEIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSK 285
            ..||...:.:||.:||.||.:|.|::....:.:.|||.|.|::..:||||.|||.||.|.|.|:.
  Fly   576 PNPKFAYTQLKVIILDEND
EAPQFSQREQNVTLGEDAPPQTIVALMTATDHDQGTNGSVTFALAP 640

Human   286 HMPPEVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQARDLG-PNPIPAHCKVLIKVLDVNDNI 349
            .:.......|::||.|||:..|||||.||...||:.|.|||.| |.|..|...|.:.|.|||||.
  Fly   641 SVERLYPLQFALDALTGQLTTRRPLDREKMSQYEISVIARDQGAPTPQSATATVWLNVADVNDND 705

Human   350 PSI---HVTWA----SQPSLVSEALPKDSFIALVMADDLDSGNNGLV------------------ 389
            |..   |..::    .....:.:.:.|:..:..|.|.|.|.|:|.|:                  
  Fly   706 PQFYPRHYIYSLADDDDDIKLKKEVEKERILLHVTASDKDDGDNALIEYRLESGGEGLFQLDARS 770

Human   390 --------------------------------------------------HCWLSQ--------- 395
                                                              .|..:|         
  Fly   771 GAISLRGDAPASMHWKPHYKLLVSARDAGQRRSQQDAIVEIVLKSKLEMLECGQAQAGGYEFQMV 835

Human   396 -------------ELGHFRLKRTNG--NTYM---------------------LLTNATLDREQWP 424
                         |:|..::|.|||  |:::                     :.|...||||:..
  Fly   836 EDHEQQRNSQPNREVGIVQVKSTNGKANSHIEYDIIQGDRAQNFRIDTRSGRITTARPLDREEQA 900

Human   425 KYTLTLLAQ-------------------------------------------------------- 433
            .|.||:||.                                                        
  Fly   901 NYRLTILASSSSSSSAAASSVSYGQCIVNIAIIDLNDNAPVFALDRESEPTISLPENAAVGQEIY 965

Human   434 ---------------------------------------------------------DQGLQPLS 441
                                                                     |.|..|||
  Fly   966 LSRVRDRDAGVNSRISYSLTNNPNQQFRIGPVTGVLYLQRPIRAEPGSLIHVELMATDAGSPPLS 1030

Human   442 AKKQLSIQISDINDNAPVFEKSRYEVSTRENNLPSLHLITIKAHDADLGINGKVSYRIQDSPVAH 506
            :|..||:.|:|:||:.|||:.:.||.|..|....:.....:.|.|.|||.||::||.|       
  Fly  1031 SKLSLSVLIADVNDHTPVFDHTSYETSLPETTKVNTRFFALAATDIDLGDNGRISYEI------- 1088

Human   507 LVAIDSNT---------GEVTAQRSLNYEEMAGFEFQVIAEDSGQPMLASSVSVWVSLLDANDNA 562
               |:.||         |.:..:..|:.||...:...|...|:|||..:|.|.|.:.::|.||||
  Fly  1089 ---IEGNTERMFGVFPDGYLFVRAPLDREERDYYALTVSCRDAGQPSRSSVVPVVIHVIDENDNA 1150

Human   563 PEVVQPVLS------------DGK-----------ASLSVLVNASTGHLLVPIETPNGL------ 598
            |:......:            .||           |.||..:::.|...  .|:|.||.      
  Fly  1151 PQFTNSTFTFSIPENAPADTFVGKLTAVDRDIGRNAELSFTLSSQTQDF--TIDTRNGFIKTLRP 1213

Human   599 ----------------GPAGT--------------------------------------DTPP-- 607
                            |..|:                                      |..|  
  Fly  1214 FDREALVKVSRNAEASGEDGSLRGSMAGNYMLLEATVSDNGIPRLQDKVKVKVIVTDVNDNAPEF 1278

Human   608 --------LATHSSRPFLLTTIVARDADSGANGEPLYSIRSGNEAHLFILNPHTGQL-------- 656
                    ::..:|....:|.:..:|||.|.||:..||:..||||..|.|:..||||        
  Fly  1279 LRAPYHVTISEGASEGTHITHVFTQDADEGLNGDVYYSLAKGNEAGQFNLDSATGQLSLGRRLDR 1343

Human   657 -------FVNVTNASSL---IGSEWELEIVVEDQ----------------------GSPPLQTRA 689
                   .:.|...::|   :.|...:.|||.|:                      |:..::.||
  Fly  1344 ESQEIHHLIVVAKDAALKHPLSSNASITIVVLDENDNAPEFTQSSSEVSVLETSPTGTELMRFRA 1408

Human   690 L-------LRVMFVTSVDHLRDS-----------ARKPGALSMSMLTVICLAVL---LGIFGLIL 733
            .       .:|:|..|..:.||:           ..||  |....:|...|.:.   .|...|..
  Fly  1409 SDADQGVNSQVVFSISAGNRRDTFHIDSITGSLYLHKP--LDYEDITSYTLNITASDCGTPSLST 1471

Human   734 ALFMSICRTEKKDN--------------------------------RAYNCREAESTYRQQPKRP 766
            .:..::...:..||                                ...|.:.:.:..:|:|:.|
  Fly  1472 TVLYNVLVVDDNDNPPIFPSTAIVRQIKEGIPLKTPIVTVTADDPDSGLNGKVSYAISKQEPQLP 1536

Human   767 Q-KHIQKADIHLVPVLRGQAGEPCEVGQSH--KDVDKEAMMEAGWDPCLQAPFHLTPTLYRTLRN 828
            | :|.               |...|.|..|  :::|:|::          ..|.|  |:..|.|.
  Fly  1537 QGRHF---------------GINTETGVIHTLREIDRESI----------DTFRL--TVVATDRA 1574

Human   829 QGNQGAPAESREVLQDTVNLLFNHPRQRNASRENLNLPEPQPATGQPRSRPLKVAGSPTGRLAGD 893
            |     |:|.:...:..|.::.          |::|...|...:......|.|.:.|        
  Fly  1575 Q-----PSERQLSTEKLVTVIV----------EDINDNAPVFVSMNAAILPPKFSTS-------- 1616

Human   894 QGSEEAPQRPPASSATLRRQRHLNGKVSPEKESGPRQILRSLVRLSVAAFAERNPVEELTVDSPP 958
            :||..|..:..|..|    ....||.|:.|..|||:::.:......:..|   .|..:..     
  Fly  1617 KGSSTAVMQVHAKDA----DSSSNGLVTYEIVSGPQELFKLQRNTGIITF---TPGPQFK----- 1669

Human   959 VQQISQLLSLLHQGQFQPKPNHRGNKYLA----KPGGSRSAIPDTDGPSARAGGQTDPEQEEGPL 1019
             |::...|:|....:...........|:.    ..|||.|::|..:..|..:|...:.|    |:
  Fly  1670 -QEVRYQLTLKSTDEAVQSERRSSEVYITIITPGSGGSESSVPQFEQRSKLSGSVYENE----PI 1729

Human  1020 DPEEDLSVKQLLEEELSSLLDPSTGLA----LDRLSAPDPAWMARLSLPLTTNYRDNVISPDAAA 1080
            ..........|...|:...:...|...    :|||...|    |:|.:..|....|....|:...
  Fly  1730 GTSILTVTAHLASAEIEYFVTNVTATGSRGQVDRLFDID----AKLGILSTAAELDREAGPEEYE 1790

Human  1081 TE--------EPRTFQTFGKAEAPELSPTGTRLAST-FVSEMSSLLEM 1119
            .|        :|||.:|..:....:.:.:..:...| ||..:|..|::
  Fly  1791 VEVYAIALGGQPRTSRTKVRVTVLDKNDSPPQFLDTPFVYNVSEDLQI 1838

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PCDH12XP_054208724.1 Cadherin_2 31..111 CDD:462413 18/80 (23%)
Cadherin_repeat 139..240 CDD:206637 36/104 (35%)
Cadherin_repeat 251..348 CDD:206637 45/97 (46%)
Cadherin_repeat 363..456 CDD:206637 38/318 (12%)
Cadherin_repeat 465..561 CDD:206637 31/104 (30%)
Cadherin_repeat 617..693 CDD:206637 29/122 (24%)
ftNP_477497.1 Cadherin_repeat 71..152 CDD:206637
Cadherin_repeat 163..266 CDD:206637
Cadherin_repeat 275..378 CDD:206637
Cadherin_repeat 393..490 CDD:206637 23/100 (23%)
Cadherin_repeat 498..594 CDD:206637 35/103 (34%)
Cadherin_repeat 603..704 CDD:206637 45/100 (45%)
Cadherin_repeat 735..814 CDD:206637 7/78 (9%)
Cadherin 843..>907 CDD:394985 15/63 (24%)
Cadherin 950..1026 CDD:394985 1/75 (1%)
Cadherin_repeat 1053..1149 CDD:206637 31/105 (30%)
Cadherin_repeat 1157..1274 CDD:206637 12/118 (10%)
Cadherin_repeat 1282..1380 CDD:206637 27/97 (28%)
Cadherin_repeat 1390..1485 CDD:206637 15/96 (16%)
Cadherin_repeat 1497..1597 CDD:206637 23/141 (16%)
Cadherin_repeat 1621..1699 CDD:206637 16/90 (18%)
Cadherin_repeat 1720..1818 CDD:206637 20/105 (19%)
Cadherin_repeat 1827..1918 CDD:206637 4/12 (33%)
Cadherin_repeat 1926..2023 CDD:206637
Cadherin_repeat 2031..2162 CDD:206637
Cadherin_repeat 2172..2274 CDD:206637
Cadherin_repeat 2282..2380 CDD:206637
Cadherin_repeat 2388..2487 CDD:206637
Cadherin_repeat 2495..2592 CDD:206637
Cadherin_repeat 2600..2694 CDD:206637
Cadherin_repeat 2710..2806 CDD:206637
Cadherin_repeat 2814..2909 CDD:206637
Cadherin_repeat 2917..3009 CDD:206637
Cadherin 3018..3114 CDD:394985
Cadherin 3129..3220 CDD:394985
Cadherin_repeat 3233..3330 CDD:206637
Cadherin_repeat 3338..3434 CDD:206637
Cadherin_repeat 3443..3541 CDD:206637
Cadherin_repeat 3550..3647 CDD:206637
Cadherin_repeat 3657..3753 CDD:206637
EGF 4017..4047 CDD:394967
EGF_CA 4056..4090 CDD:238011
EGF_CA 4094..4128 CDD:238011
Laminin_G_1 4156..4306 CDD:395008
LamG 4428..4543 CDD:238058
Blue background indicates that the domain is not in the aligned region.

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