Protein Alignment KLF3 and hkb

DIOPT Version :10

• Sequence 1: NP_057615.3
• Gene: KLF3 / 51274
• HGNCID: 16516
• Length: 345
• Species: Homo sapiens
• Sequence 2: NP_524221.1
• Gene: hkb / 40549
• FlyBaseID: FBgn0261434
• Length: 297
• Species: Drosophila melanogaster
• Alignment Length: 346
• Identity: 84/346 - (24%)
• Similarity: 130/346 - (37%)
• Gaps: 86/346 - (24%)

Human    14 MDPVSVSYPSNYMESMKP---NKYGVIYSTPLPEKFFQTPEGLSHGIQMEPV------DLTVNKR 69
            |..:::..|..|....:|   .:.....:.|...|  |.||.::  |:.|..      |...:..
  Fly     1 MSTINLHPPQTYSRLFRPWDTQRQAATSAAPRTVK--QEPEAIT--IKTELASSSFGHDCDGDFS 61

Human    70 SSPPSAGNSPSSLKFPSSHRRASPGLSMPSSSPPIKKYSPPSPGVQP-FGVPLSMPPVMAAALSR 133
            |:..||.:|.:|.|  |.:..|....|...:|.|:...:|     .| |..|.|.|      |..
  Fly    62 SASSSASSSSNSSK--SCYEEALNHSSYTRTSTPLLDAAP-----HPVFSHPQSSP------LDT 113

Human   134 HGIRSPGILPVIQPVVVQPVPFMYTSHLQQPLMVSLSEEMENSSSSMQVPVIESYEKPISQKKIK 198
            |...:..:.|     ..|..||:  |........:.:.....:|:...||..
  Fly   114 HAAATASLAP-----PNQHAPFL--SAASDLYYAAAAAAAAAASTPTAVPGF------------- 158

Human   199 IEPGIEPQRTDYYPEEMSPPLMNSVSPPQALLQENHPSVIVQPGKRPLPVESPDTQ------RKR 257
               |::|.                   ...|:::.:..|:.:           |.|      ||:
  Fly   159 ---GMDPF-------------------TMGLMEQEYARVMAE-----------DAQLKALNSRKQ 190

Human   258 RIHRCDYDGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHFRKHTGIKPFQC 322
            |..:.....|:..::.:..||.|.|.||||:|:||....|...|.|::|||||.|.|||::|:.|
  Fly   191 RPKKFKCPNCDVAFSNNGQLKGHIRIHTGERPFKCDVNTCGKTFTRNEELTRHKRIHTGLRPYPC 255

Human   323 PDCDRSFSRSDHLALHRKRHM 343
            ..|.:.|.|.|||..|.|.||
  Fly   256 SACGKKFGRRDHLKKHMKTHM 276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLF3	NP_057615.3	Repressor domain	1..74		13/68 (19%)
		KLF3_N	49..260	CDD:410554	41/223 (18%)
		9aaTAD, inactive. /evidence=ECO:0000269|PubMed:31375868	60..68		2/13 (15%)
		CTBP-binding motif	61..65		1/9 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	66..112		12/45 (27%)
		zf-C2H2	260..284	CDD:395048	5/23 (22%)
		C2H2 Zn finger	262..284	CDD:275368	5/21 (24%)
		C2H2 Zn finger	292..314	CDD:275368	10/21 (48%)
		zf-H2C2_2	306..331	CDD:463886	13/24 (54%)
		C2H2 Zn finger	322..342	CDD:275368	9/19 (47%)
hkb	NP_524221.1	COG5048	195..>261	CDD:227381	27/65 (42%)
		C2H2 Zn finger	197..217	CDD:275368	5/19 (26%)
		C2H2 Zn finger	225..247	CDD:275368	10/21 (48%)
		zf-C2H2	253..275	CDD:395048	9/21 (43%)
		C2H2 Zn finger	255..275	CDD:275368	9/19 (47%)