Protein Alignment KLF3 and Sp1

DIOPT Version :10

• Sequence 1: NP_057615.3
• Gene: KLF3 / 51274
• HGNCID: 16516
• Length: 345
• Species: Homo sapiens
• Sequence 2: NP_001259388.1
• Gene: Sp1 / 31913
• FlyBaseID: FBgn0020378
• Length: 726
• Species: Drosophila melanogaster
• Alignment Length: 387
• Identity: 103/387 - (26%)
• Similarity: 139/387 - (35%)
• Gaps: 116/387 - (29%)

Human    52 GLSHGIQMEP--VDLTVNKRSSPPSAGNSPSSLK--------------FPSSHRRASPGLSMPSS 100
            |.|.| |..|  :....:..||..|.|.|..||.              ..||......|.:..||
  Fly   101 GSSAG-QHSPCAISAASSSSSSGSSGGQSSRSLSSSASTMVNITASRPLASSCAAVGGGSTGSSS 164

Human   101 SPPIKKYSPPSPGV-QPFGVPLSMPPVMAAALSRHGIRSPGILPVIQPVVV--------QPV--P 154
            |....:.|..:..| ..:|..|..|....:.:..|.:.. |:|..::....        .|.  |
  Fly   165 SASGSQSSSTASAVAAAYGGDLYFPNTSTSNMDNHHMHQ-GLLGKVEAGAAAFGGVYSRHPYDWP 228

Human   155 FMYTSHLQQPLMVSLSEEMENSSSSMQVPVIESYEKPISQKKIKIE---PGIEPQRTDYYPEEMS 216
            |...:|.:...:.|...:|.:::.|.                  ::   .|:.....:|..|..|
  Fly   229 FNAVTHKEAASVNSGWWDMHSAAGSW------------------LDMGGAGMHSTMANYASENYS 275

Human   217 PPLMNS-VSPPQALLQENHPSVI----------VQPGKRPLPVESPDTQ---------------- 254
            ..|.:| :...|.|||:.:.|::          |..|...||..||...
  Fly   276 SALSHSLLGSGQHLLQDTYKSMLPGQGVGVGVGVGMGGFSLPHSSPSAAAAAAATAAAAAGGSPQ 340

Human   255 ---------------------------------------RKRRIHRCDYDGCNKVYTKSSHLKAH 280
                                                   ||:.||.|...||.|||.|:||||||
  Fly   341 GGSPSTPSPRSQRRYAGRATCDCPNCQEAERLGPAGVHLRKKNIHSCHIPGCGKVYGKTSHLKAH 405

Human   281 RRTHTGEKPYKCTWEGCTWKFARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDHLALHRKRH 342
            .|.||||:|:.|.|..|..:|.|||||.||.|.|||.|.|.||.|::.|.||||||.|.|.|
  Fly   406 LRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLAKHVKTH 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLF3	NP_057615.3	Repressor domain	1..74		7/23 (30%)
		KLF3_N	49..260	CDD:410554	52/303 (17%)
		9aaTAD, inactive. /evidence=ECO:0000269|PubMed:31375868	60..68		1/9 (11%)
		CTBP-binding motif	61..65		1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	66..112		14/59 (24%)
		zf-C2H2	260..284	CDD:395048	15/23 (65%)
		C2H2 Zn finger	262..284	CDD:275368	14/21 (67%)
		C2H2 Zn finger	292..314	CDD:275368	12/21 (57%)
		zf-H2C2_2	306..331	CDD:463886	14/24 (58%)
		C2H2 Zn finger	322..342	CDD:275368	12/19 (63%)
Sp1	NP_001259388.1	SP6-9-like_N	50..386	CDD:411694	53/304 (17%)
		C2H2 Zn finger	390..409	CDD:275368	13/18 (72%)
		zf-H2C2_2	401..428	CDD:463886	15/26 (58%)
		C2H2 Zn finger	417..439	CDD:275368	12/21 (57%)
		zf-H2C2_2	431..454	CDD:463886	13/22 (59%)
		zf-C2H2	445..467	CDD:395048	13/21 (62%)
		C2H2 Zn finger	447..467	CDD:275368	12/19 (63%)