Protein Alignment KLF3 and btd

DIOPT Version :10

• Sequence 1: NP_057615.3
• Gene: KLF3 / 51274
• HGNCID: 16516
• Length: 345
• Species: Homo sapiens
• Sequence 2: NP_511100.1
• Gene: btd / 31912
• FlyBaseID: FBgn0000233
• Length: 644
• Species: Drosophila melanogaster
• Alignment Length: 332
• Identity: 93/332 - (28%)
• Similarity: 129/332 - (38%)
• Gaps: 94/332 - (28%)

Human    71 SPPSAGNSPSSLKFP----SSHRRASPGLSMPSSSPPIKKYSP---PSPGVQPF-------GVPL 121
            |.|..|..|..|:.|    ||...|||..|: .|:|.....||   ||| .|.|       ..|.
  Fly   116 SSPLYGKPPMKLELPYPQASSTGTASPNSSI-QSAPSSASVSPSIFPSP-AQSFASISASPSTPT 178

Human   122 S--MPPVMAAALSRHGIRSPGILPVIQPVVVQPVPFMYTSHLQQPLMVSLSEEMENSSSSMQVPV 184
            :  .||..|||.:..|  ||                           .|.|.....:|::.....
  Fly   179 TTLAPPTTAAAGALAG--SP---------------------------TSSSPSSSAASAAAAAAA 214

Human   185 IESYEKPISQKKI--------KIEPGIEPQRTDY-YPEEMSPPLMNSVSPPQALLQENHPSVIVQ 240
            ..:....:....:        ....|:.|.|:.: |.:..|....|:|....:....:|...:.|
  Fly   215 AAAAAADLGAAAVASAAYGWNTAYSGLGPARSQFPYAQYASDYYGNAVGMSSSAAWFSHQERLYQ 279

Human   241 P--------------------GKRPL---------------PVESPDTQRKRRIHRCDYDGCNKV 270
            |                    .:|.:               |:..|| :|.|:.|.|...||.::
  Fly   280 PWSSQSYPGFNFDDIAFQTQLQRRSVRCTCPNCTNEMSGLPPIVGPD-ERGRKQHICHIPGCERL 343

Human   271 YTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDHL 335
            |.|:||||.|.|.||||:|:.|.  .|..:|:|||||.||.|.||..:|:.||.|.:.|||||||
  Fly   344 YGKASHLKTHLRWHTGERPFLCL--TCGKRFSRSDELQRHGRTHTNYRPYACPICSKKFSRSDHL 406

Human   336 ALHRKRH 342
            :.|:|.|
  Fly   407 SKHKKTH 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLF3	NP_057615.3	Repressor domain	1..74		1/2 (50%)
		KLF3_N	49..260	CDD:410554	49/248 (20%)
		9aaTAD, inactive. /evidence=ECO:0000269|PubMed:31375868	60..68
		CTBP-binding motif	61..65
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	66..112		17/47 (36%)
		zf-C2H2	260..284	CDD:395048	12/23 (52%)
		C2H2 Zn finger	262..284	CDD:275368	11/21 (52%)
		C2H2 Zn finger	292..314	CDD:275368	11/21 (52%)
		zf-H2C2_2	306..331	CDD:463886	12/24 (50%)
		C2H2 Zn finger	322..342	CDD:275368	12/19 (63%)
btd	NP_511100.1	C2H2 Zn finger	338..357	CDD:275368	10/18 (56%)
		zf-H2C2_2	349..374	CDD:463886	13/26 (50%)
		C2H2 Zn finger	365..385	CDD:275368	11/21 (52%)
		zf-H2C2_2	377..402	CDD:463886	12/24 (50%)
		zf-C2H2	391..413	CDD:395048	12/21 (57%)
		C2H2 Zn finger	393..413	CDD:275368	12/19 (63%)