DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CDKL3 and Cdkl3

DIOPT Version :9

Sequence 1:	XP_011541731.1	Gene:	CDKL3 / 51265	HGNCID:	15483	Length:	619	Species:	Homo sapiens
Sequence 2:	XP_006532830.1	Gene:	Cdkl3 / 213084	MGIID:	2388268	Length:	638	Species:	Mus musculus

Alignment Length:	590	Identity:	463/590 - (78%)
Similarity:	519/590 - (87%)	Gaps:	14/590 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLVNL 65
            ||||||||||||||||||||||||:||:|||||||||:||:||||||.|||||||||.|||||||
Mouse     1 MEMYETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKIATREIKFLKQFRHENLVNL 65

Human    66 IEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNIIHRDIKPEN 130
            ||||||||||||||||||||||||||||||||||||||||||||||||:|||:||||||||||||
Mouse    66 IEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIEYLHNNNIIHRDIKPEN 130

Human   131 ILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKYVYFGILSAFPRPVD 195
            |||||||||||||||||||||||||:||||||||||||||||||||||||            |||
Mouse   131 ILVSQSGITKLCDFGFARTLAAPGDVYTDYVATRWYRAPELVLKDTSYGK------------PVD 183

Human   196 IWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQVQHPKNA 260
            ||||||||||||||:|:||||||||||||||||||||:|||.|||||||||||||||||||||.|
Mouse   184 IWALGCMIIEMATGHPFLPSSSDLDLLHKIVLKVGNLTPHLHNIFSKSPIFAGVVLPQVQHPKTA 248

Human   261 RKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELKAKLLQEAKVNSLI 325
            ||||||||||||||||||||||||:|.||:|||.|:|||||||||||:|||:|||||||||||.|
Mouse   249 RKKYPKLNGLLADIVHACLQIDPAERTSSTDLLRHDYFTRDGFIEKFIPELRAKLLQEAKVNSFI 313

Human   326 KPKESSKENELRKDERKTVYTNTLL--SSSVLGKEIEKEKKPKEIKVRVIKVKGGRGDISEPKKK 388
            ||||:.||||..:||:|:|:|||||  :.|:.|||::::|:.||:||||||.|||:||:.:.||.
Mouse   314 KPKENFKENEPVRDEKKSVFTNTLLYGNPSLYGKEVDRDKRAKELKVRVIKAKGGKGDVPDQKKP 378

Human   389 EYEGGLGQQDANENVHPMSPDTKLVTIEPPNPINPSTNCNGLKENPHCGGSVTMPPINLTNSNLM 453
            ||||...||...::..|.|.|.|...:|..||:|||.|.:|:||:||.||.:.|||||||:|||:
Mouse   379 EYEGDHRQQGTADDTQPSSLDKKPSVLELTNPLNPSENSDGVKEDPHAGGCMIMPPINLTSSNLL 443

Human   454 AANLSSNLFHPSVRLTERAKKRRTSSQSIGQVMPNSRQEDPGPIQSQMEKGIFNERTGHSDQMAN 518
            ||||||||.||:.|||||.||||||||:|||.:.||||||.||.|.|.|||.||||||.:||:::
Mouse   444 AANLSSNLSHPNSRLTERTKKRRTSSQTIGQTLSNSRQEDTGPTQVQTEKGAFNERTGQNDQISS 508

Human   519 ENKRKLNFSRSDRKEFHFPELPVTIQSKDTKGMEVKQIKMLKRESKKTESSKIPTLLNVDQNQEK 583
            .|||||||.:.|||||||||||.|:|:|:.|||||||||:||||||||:||||||||::|.||||
Mouse   509 GNKRKLNFPKCDRKEFHFPELPFTVQAKEMKGMEVKQIKVLKRESKKTDSSKIPTLLSMDPNQEK 573

Human   584 QEFIP 588
            ||..|
Mouse   574 QETEP 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDKL3	XP_011541731.1	STKc_CDKL2_3	2..298	CDD:270836	264/295 (89%)
Cdkl3	XP_006532830.1	PKc_like	2..286	CDD:419665	264/295 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83973528
Domainoid	1	1.000	547	1.000	Domainoid score	I6293
eggNOG	1	0.900	-	-		E1_KOG0593
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49467
Inparanoid	1	1.050	977	1.000	Inparanoid score	I6008
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG35726
OrthoDB	1	1.010	-	-		D119705at32523
OrthoFinder	1	1.000	-	-		FOG0016294
OrthoInspector	1	1.000	-	-		oto122624
orthoMCL	1	0.900	-	-		OOG6_128345
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R12313
SonicParanoid	1	1.000	-	-		X13238
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	19	19.300