Protein Alignment MARCHF2 and CG17717

DIOPT Version :10

• Sequence 1: NP_057580.3
• Gene: MARCHF2 / 51257
• HGNCID: 28038
• Length: 246
• Species: Homo sapiens
• Sequence 2: NP_572327.1
• Gene: CG17717 / 31592
• FlyBaseID: FBgn0029877
• Length: 266
• Species: Drosophila melanogaster
• Alignment Length: 221
• Identity: 52/221 - (23%)
• Similarity: 85/221 - (38%)
• Gaps: 52/221 - (23%)

Human    30 GLGPPQYVA------------------------QVTSRDGRLL-STVIRALDTPSD-GPFCRICH 68
            |..|||..|                        :::|...|:| |.:..:|.:.:: |..||||.
  Fly    31 GAQPPQSAAAEAICSSQIVASAHGTPTASTAALEISSARQRMLRSHLQESLHSANESGNSCRICR 95

Human    69 EGANG-ECLLSPCGCTGTLGAVHKSCLEKWLSSSNTSYCELCHTEFAVEKRPRPLTEWLKDPGPR 132
            ...|. |.:..||.|.|::|.:|..||::|:.....:.||:|:..|.:.:....|.:.:
  Fly    96 WNRNDMEIIKCPCNCKGSVGYIHLKCLKRWIMHRRDNRCEICNAVFNIAEERASLKQMI------ 154

Human   133 TEKRTLCCDMVCFLFI---------TPLAAI---SGWLCL----RGAQDHLRLHSQLEAVGLIAL 181
               ||.||...|.|.:         .|||.|   ....|:    :|:.|.|.:.....|...:..
  Fly   155 ---RTFCCGRCCGLIVKHLLFSASLMPLAHIILQQVLQCMDNMNQGSTDQLTVQEVFVASCALLT 216

Human   182 TIALFTIYVLWTLVSFRYHCQLYSEW 207
            :.|||..:..:....|.....:.|.|
  Fly   217 SSALFFHFFEFVTTRFMLIRNILSHW 242

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARCHF2	NP_057580.3	Required for inhibition of HIV-1 virus production and VSV G protein expression. /evidence=ECO:0000269|PubMed:29573664	56..116		20/61 (33%)
		RING_CH-C4HC3_MARCH2	62..113	CDD:319722	18/51 (35%)
		Required for interaction with IKBKG. /evidence=ECO:0000269|PubMed:32935379	121..246		22/103 (21%)
CG17717	NP_572327.1	RINGv	91..138	CDD:128983	17/46 (37%)