| Sequence 1: | NP_001358972.1 | Gene: | PCSK5 / 5125 | HGNCID: | 8747 | Length: | 1887 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_727963.1 | Gene: | Fur2 / 32604 | FlyBaseID: | FBgn0004598 | Length: | 1682 | Species: | Drosophila melanogaster |
| Alignment Length: | 2000 | Identity: | 577/2000 - (28%) |
|---|---|---|---|
| Similarity: | 761/2000 - (38%) | Gaps: | 738/2000 - (36%) |
- Green bases have known domain annotations that are detailed below.
|
Human 21 LLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVI 85
Human 86 SSRGTHSFISMEPKVEWIQQQVVKKRTKRD-----------YDFSRAQSTY-------------- 125
Human 126 --------------------FNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTIL 170
Human 171 DDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAF 235
Human 236 NAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGR 300
Human 301 RGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSG-ES 364
Human 365 YDKKIITTDL------RQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGH 423
Human 424 L-NANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVC---VESTDRQIKTIRPNSA 484
Human 485 VRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGF 549
Human 550 KNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPY----------- 603
Human 604 ---SPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKN 665
Human 666 NTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQ 730
Human 731 DTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGA 795
Human 796 GADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGY 860
Human 861 LLDLGMCQMGAICKDGEYVDEHGHCQTCEASC--AKC--QGPTQEDCTTCPMTRIFDDGRCVSNC 921
Human 922 PSWKFEFENQ---CHPCHHTCQRCQGSGPTHCTSCGADNYGREHFLYQGECGDSCPEGHYATEGN 983
Human 984 TCLP-CPDNCELCHSVHVCTRCMKGYFIAPTNHTCQKLECGQGEVQDPDYEECVPCEEGCLGCSL 1047
Human 1048 DDPGTCTSCAMGYYRFDHHCYKTCPEKTYSEEVECKACDSNCGSCDQNGCYWCEEGFFLLGGSCV 1112
Human 1113 RKCGPGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNEAV 1177
Human 1178 STANLSVVKSLLQERRRWKVQIKRDILRKLQPCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSC 1242
Human 1243 PQGTWPSVRSGSCENCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSY-AEDGICER 1306
Human 1307 CSSPCRTCEGNATNCHSCEGGHVLHHGVCQENCPERHVAVKGVCKHCPEMCQDCIHEKTCKECTP 1371
Human 1372 EFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGT 1436
Human 1437 YYEKETKECRDCHKSCLTCSSSGTCTTCQKGLIMNPRGSCM--ANEKCSPSEYWDEDAPGCKPCH 1499
Human 1500 VKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHS 1564
Human 1565 CRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGECHR 1629
Human 1630 SCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFN 1694
Human 1695 CEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCCNT---SDPPSAQECCDCQDTTDEC-- 1754
Human 1755 ------------------------------------ILRTSKVRPATEHFKTALFITSSMMLVLL 1783
Human 1784 LGAAVVVWKKSRGRVQPAAKAGYEKLADPNKSYSSYKSSYRESTSFEEDQVIEY-----RDRDYD 1843
Human 1844 EDDDDD-------------IVY--MGQDGTVYRKFKYGLLDDDDIDELEY 1878 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| PCSK5 | NP_001358972.1 | S8_pro-domain | 38..114 | CDD:374560 | 35/75 (47%) |
| Peptidases_S8_Protein_convertases_Kexins_Fur in-lik | 126..420 | CDD:173789 | 188/300 (63%) | ||
| P_proprotein | 505..595 | CDD:366670 | 40/89 (45%) | ||
| Cell attachment site. /evidence=ECO:0000255 | 519..521 | 1/1 (100%) | |||
| FU 1 | 630..680 | 5/49 (10%) | |||
| GF_recep_IV | 635..744 | CDD:373332 | 10/108 (9%) | ||
| VSP | 724..1100 | CDD:146106 | 75/383 (20%) | ||
| FU | 1084..1129 | CDD:238021 | 0/44 (0%) | ||
| FU | 1126..1162 | CDD:214589 | 0/35 (0%) | ||
| FU | 1209..1256 | CDD:238021 | 0/46 (0%) | ||
| VSP | 1291..>1576 | CDD:146106 | 73/287 (25%) | ||
| GF_recep_IV | 1596..1713 | CDD:373332 | 44/116 (38%) | ||
| FU | 1695..1736 | CDD:214589 | 17/43 (40%) | ||
| AC 1. /evidence=ECO:0000250 | 1834..1853 | 9/38 (24%) | |||
| AC 2. /evidence=ECO:0000250 | 1865..1887 | 4/13 (31%) | |||
| Fur2 | NP_727963.1 | S8_pro-domain | 242..318 | CDD:293079 | 35/75 (47%) |
| Peptidases_S8_Protein_convertases_Kexins_Fur in-like | 375..674 | CDD:173789 | 188/300 (63%) | ||
| Peptidase_S8 | 411..700 | CDD:278510 | 185/290 (64%) | ||
| P_proprotein | 761..849 | CDD:279782 | 40/89 (45%) | ||
| Furin-like | 966..1126 | CDD:279142 | 78/525 (15%) | ||
| FU | 970..1013 | CDD:238021 | 20/48 (42%) | ||
| FU | 1017..1067 | CDD:238021 | 22/102 (22%) | ||
| FU | 1063..1106 | CDD:214589 | 26/283 (9%) | ||
| GF_recep_IV | 1068..1232 | CDD:291509 | 72/478 (15%) | ||
| FU | 1116..1163 | CDD:238021 | 20/138 (14%) | ||
| FU | 1211..1255 | CDD:214589 | 20/43 (47%) | ||
| FU | 1259..1301 | CDD:214589 | 12/43 (28%) | ||
| FU | 1304..1348 | CDD:214589 | 18/47 (38%) | ||
| FU | 1356..1403 | CDD:238021 | 16/49 (33%) | ||
| FU | 1401..1444 | CDD:214589 | 17/42 (40%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 228 | 1.000 | Domainoid score | I2495 |
| eggNOG | 1 | 0.900 | - | - | E1_COG1404 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H21244 | |
| Inparanoid | 1 | 1.050 | 771 | 1.000 | Inparanoid score | I536 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S3236 |
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D311719at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0000204 | |
| OrthoInspector | 1 | 1.000 | - | - | otm41305 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_100362 | |
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X4005 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 12 | 11.720 | |||||