Protein Alignment VRK3 and Asator

DIOPT Version :10

• Sequence 1: NP_057524.3
• Gene: VRK3 / 51231
• HGNCID: 18996
• Length: 474
• Species: Homo sapiens
• Sequence 2: NP_651924.2
• Gene: Asator / 43794
• FlyBaseID: FBgn0039908
• Length: 1349
• Species: Drosophila melanogaster
• Alignment Length: 499
• Identity: 107/499 - (21%)
• Similarity: 182/499 - (36%)
• Gaps: 151/499 - (30%)

Human    79 DGD-----SSESEDTLSSSERSKGSGSR--PPTPKSSPQ------KTRKSPQVTRGSP------- 123
            ||:     ||:.:..||.:...:.:..|  ||.|...|.      :||...|:   ||
  Fly    19 DGNQSCQPSSKQDQYLSPNRNCQKNLLRLYPPPPSKPPPLVGAILQTRLLHQI---SPSAIADAD 80

Human   124 ---------------QKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQT 173
                           |:::..|.|..:..   .|||||..   :|:..:....|...........
  Fly    81 ADLNAVGELLYPNVLQRSATLPAKHNRLG---VRSRVTFK---VPSSNLPAQDSYSHQPRNQVAV 139

Human   174 RDNQGILYEAAPTSTLTCDSGPQKQKFSLKLDAKD-----------------------GRLFNEQ 215
            ....|||.:.             |.|.|:|:.::|                       |.::..|
  Fly   140 AAKDGILVDV-------------KAKESVKMTSEDLLQPGHVVKERWKVVRKIGGGGFGEIYEGQ 191

Human   216 NFFQR---------AAKPLQVNKW-----KKLYSTPLLAIPTCMGFGV-HQDKYRFLVLPSLGRS 265
            :...|         |.:|.||.|.     |||....    ..|...|. ..|::.::|:...|::
  Fly   192 DLITREQVALKVESARQPKQVLKMEVAVLKKLQGKE----HVCRFIGCGRNDRFNYVVMQLQGKN 252

Human   266 LQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVD--PEDQSQVTLAGYG 328
            |.......|:...|..:.|::..::|.|:|.:|...::|.::...|..|.  |.:..:|.:..:|
  Fly   253 LAELRRAQPRGAFSLSTTLRLGLQILKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRVYMLDFG 317

Human   329 FAFRY--------CPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLY 385
            .|.:|        ||..     ..|.|    |.:.:.|::.|:.....|..||.||.|.:::::.
  Fly   318 LARQYTTGTGEVRCPRA-----AAGFR----GTVRYASINAHRNREMGRHDDLWSLFYMLVEFVN 373

Human   386 GFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWI----RPSETLQKYLKVVMALTYEEKPPY 446
            |.|||.. :.:.|.:...|:|:           .|.|    .||: |:::|:.:.:|||.::|.|
  Fly   374 GQLPWRK-IKDKEQVGLTKEKY-----------DHRILLKHLPSD-LKQFLEHIQSLTYGDRPDY 425

Human   447 AMLRNNLEALLQDLRVSPYDP----------------IGLPMVP 474
            |||....|..::...|...||                .|.|.:|
  Fly   426 AMLIGLFERCMKRRGVKESDPYDWEKVDSTAIGNISATGNPSIP 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VRK3	NP_057524.3	zinc_ribbon_2	4..24	CDD:433054
		PHA03307	<40..>165	CDD:223039	26/120 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	41..152		24/107 (22%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:14645249	49..64
		Protein Kinases, catalytic domain	155..457	CDD:473864	76/353 (22%)
Asator	NP_651924.2	STKc_TTBK	172..433	CDD:270919	66/286 (23%)