Protein Alignment VRK3 and dco

DIOPT Version :10

• Sequence 1: NP_057524.3
• Gene: VRK3 / 51231
• HGNCID: 18996
• Length: 474
• Species: Homo sapiens
• Sequence 2: NP_524602.1
• Gene: dco / 43673
• FlyBaseID: FBgn0002413
• Length: 440
• Species: Drosophila melanogaster
• Alignment Length: 288
• Identity: 73/288 - (25%)
• Similarity: 129/288 - (44%)
• Gaps: 41/288 - (14%)

Human   190 TCDSGPQKQKFSLKLD---AKDGRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQ 251
            |.::|   ::.::||:   .|..:|..|..|:    |.:|..          :.||..:..|...
  Fly    28 TINTG---EEVAIKLECIRTKHPQLHIESKFY----KTMQGG----------IGIPRIIWCGSEG 75

Human   252 DKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVD- 315
            | |..:|:..||.||:...:...:. .|.::||.:|.:::..::::|..:::|.::..:|..:.
  Fly    76 D-YNVMVMELLGPSLEDLFNFCSRR-FSLKTVLLLADQMISRIDYIHSRDFIHRDIKPDNFLMGL 138

Human   316 PEDQSQVTLAGYGFA--FRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGY 378
            .:..:.|.:..:|.|  ||...|.||:.|.|....  .|...:.|::.|.|...|||.||:||||
  Fly   139 GKKGNLVYIIDFGLAKKFRDARSLKHIPYRENKNL--TGTARYASINTHLGIEQSRRDDLESLGY 201

Human   379 CMLKWLYGFLPW-----TNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMAL 438
            .::.:..|.|||     .|.....|.|.::|..     ...|..|..:  |||.: .||.....:
  Fly   202 VLMYFNLGALPWQGLKAANKRQKYERISEKKLS-----TSIVVLCKGF--PSEFV-NYLNFCRQM 258

Human   439 TYEEKPPYAMLRNNLEALLQDLRVSPYD 466
            .::::|.|..||.....|...|..: ||
  Fly   259 HFDQRPDYCHLRKLFRNLFHRLGFT-YD 285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VRK3	NP_057524.3	zinc_ribbon_2	4..24	CDD:433054
		PHA03307	<40..>165	CDD:223039
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	41..152
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:14645249	49..64
		Protein Kinases, catalytic domain	155..457	CDD:473864	69/277 (25%)
dco	NP_524602.1	STKc_CK1_delta_epsilon	8..282	CDD:271027	71/282 (25%)