Protein Alignment VRK3 and CG9962

DIOPT Version :10

• Sequence 1: NP_057524.3
• Gene: VRK3 / 51231
• HGNCID: 18996
• Length: 474
• Species: Homo sapiens
• Sequence 2: NP_608697.1
• Gene: CG9962 / 33448
• FlyBaseID: FBgn0031441
• Length: 319
• Species: Drosophila melanogaster
• Alignment Length: 232
• Identity: 67/232 - (28%)
• Similarity: 113/232 - (48%)
• Gaps: 28/232 - (12%)

Human   246 GFGVHQDKYRF--------LVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEY 302
            |.|:.. .|:|        ||:..||.||::...:..:. .|.::||.:|.:::|.||:||.:.|
  Fly    68 GMGIPM-TYQFFSNRRHDVLVMELLGPSLETLFTMCNRR-FSMKTVLMLADQMVDRLEYLHLHHY 130

Human   303 VHGNVTAENIFVDPE-DQSQVTLAGYGFAFRY--CPSGKHVAYVEGSRSPHEGDLEFISMDLHKG 364
            ||.::..||..:... .:.::.|..:|.:.||  ....:||....|::  ..|...:.|::....
  Fly   131 VHRDIKPENFLMGVGLTRHRLHLIDFGLSKRYWDMKENRHVPQRRGTK--WAGTARYASVNALCC 193

Human   365 CGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNT-----EDIMKQKQKFVDKPGPFVGPCGHWIRP 424
            ...|||.||:|:||.::..|.|.|||...|||:     |.|::.|...:  |...   |..:  |
  Fly   194 KVQSRRDDLESVGYVLIYLLRGSLPWQGLLPNSKLQKAEMILEMKLSTL--PNSL---CAGY--P 251

Human   425 SETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLR 461
            :| ...|:.....|.:||:|.|.|:|....:||.:|:
  Fly   252 NE-FYNYIIYTRQLGFEEEPDYRMIRCTFLSLLFNLK 287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VRK3	NP_057524.3	zinc_ribbon_2	4..24	CDD:433054
		PHA03307	<40..>165	CDD:223039
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	41..152
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:14645249	49..64
		Protein Kinases, catalytic domain	155..457	CDD:473864	64/226 (28%)
CG9962	NP_608697.1	STKc_CK1	17..279	CDD:270918	64/222 (29%)