Protein Alignment ZNF219 and CG4707

DIOPT Version :10

• Sequence 1: NP_057507.2
• Gene: ZNF219 / 51222
• HGNCID: 13011
• Length: 722
• Species: Homo sapiens
• Sequence 2: NP_611944.1
• Gene: CG4707 / 37935
• FlyBaseID: FBgn0035036
• Length: 673
• Species: Drosophila melanogaster
• Alignment Length: 319
• Identity: 70/319 - (21%)
• Similarity: 102/319 - (31%)
• Gaps: 89/319 - (27%)

Human    55 RRFPCPV----------------------------CGKRFRFNSILALHLRAHPGAQAFQCPHCG 91
            ::|||.:                            ||::|.....||.|:..|.....|.|..||
  Fly   330 KKFPCSLCNLLVQNFADMRRHQRVSHNIESGYIECCGRKFHLRKALAEHVLVHKNPDHFMCSQCG 394

Human    92 HRAAQRALLRSHLRTH-QPERPRSPAARLLLELEERALLREARLGRARSSGGMQATPATEGLARP 155
            ........|..|.:|| .||....|..:.:.:.|           :...|...:|......:::.
  Fly   395 RVFQDSRALEVHEQTHTNPEVKAEPKEKRIYQCE-----------KCPKSFTTKAAMEYHDVSKH 448

Human   156 QAPSSSAFRCPYCKGKFRTSAERERHLHILHRPW------KCGLCSFGSSQEEELLHHSLTAHGA 214
            ...|...:.||.|..|..|..:.:.||..:|.|.      |||...  .||.....||.|
  Fly   449 VPKSEFKYSCPECNKKIPTERKLKEHLRYMHDPEAAIICDKCGKTL--RSQTNLKKHHEL----- 506

Human   215 PERPLAATSAAPPPQPQPQPPPQPEPRSVPQPEPEPEPEREATPT---------PAPAAPEEPPA 270
                                    |....|:|:|:| .:.|...|         .......|||.
  Fly   507 ------------------------EHSEKPRPKPDP-VQCEICGTWLRHLSGLKQHMKTVHEPPG 546

Human   271 PPEFRCQVCGQSFTQSWFLKGHM-RKHKASFDHACPVCGRCFKEPWFLKNHMKVHASKL 328
             .|.||.:|.::.|.|..||.|: ..|.......|.:|.:.||.|..|:.|...|..::
  Fly   547 -DEHRCHICNKTSTNSRALKRHIYHNHLCERKFKCGMCEKAFKRPQDLREHTSTHTGEV 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZNF219	NP_057507.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		RPC10	53..>93	CDD:441599	14/65 (22%)
		C2H2 Zn finger	59..79	CDD:275368	7/47 (15%)
		zf-C2H2	85..107	CDD:395048	6/21 (29%)
		C2H2 Zn finger	87..107	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	137..160		2/22 (9%)
		C2H2 Zn finger	165..183	CDD:275368	6/17 (35%)
		C2H2 Zn finger	191..207	CDD:275368	4/15 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	215..275		11/68 (16%)
		zf-C2H2	274..296	CDD:395048	8/22 (36%)
		C2H2 Zn finger	276..296	CDD:275368	7/20 (35%)
		zf-C2H2	302..324	CDD:395048	7/21 (33%)
		C2H2 Zn finger	304..324	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	384..495
		PTZ00449	<453..>612	CDD:185628
		C2H2 Zn finger	500..520	CDD:275368
		zf-C2H2	500..520	CDD:395048
		zf-H2C2_2	512..537	CDD:463886
		C2H2 Zn finger	528..548	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	542..648
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	668..722
CG4707	NP_611944.1	zf-AD	3..77	CDD:462262
		C2H2 Zn finger	334..355	CDD:275368	1/20 (5%)
		LIM	<361..407	CDD:413332	12/45 (27%)
		C2H2 Zn finger	365..382	CDD:275368	6/16 (38%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		C2H2 Zn finger	427..443	CDD:275368	3/26 (12%)
		COG5236	<455..>574	CDD:227561	37/151 (25%)
		C2H2 Zn finger	458..476	CDD:275368	6/17 (35%)
		C2H2 Zn finger	487..507	CDD:275368	8/50 (16%)
		C2H2 Zn finger	521..540	CDD:275368	2/18 (11%)
		C2H2 Zn finger	551..572	CDD:275368	7/20 (35%)
		C2H2 Zn finger	580..600	CDD:275368	7/19 (37%)
		C2H2 Zn finger	608..629	CDD:275368