Protein Alignment ZNF219 and wor

DIOPT Version :10

• Sequence 1: NP_057507.2
• Gene: ZNF219 / 51222
• HGNCID: 13011
• Length: 722
• Species: Homo sapiens
• Sequence 2: NP_476601.1
• Gene: wor / 34906
• FlyBaseID: FBgn0001983
• Length: 548
• Species: Drosophila melanogaster
• Alignment Length: 687
• Identity: 129/687 - (18%)
• Similarity: 195/687 - (28%)
• Gaps: 335/687 - (48%)

Human   198 SSQEEELLHHSLTAHGAPERP--LAATSAAPPPQP----QPQPPPQPEP---------------- 240
            ||.|:.|.|        .|.|  |:..|||.|.:|    :.:|.|||.|
  Fly    21 SSPEDHLSH--------DEGPVDLSVASAAVPMEPHWMAKSEPEPQPVPTELRRRFDAAMNQTKE 77

Human   241 --------------RSVPQ---------------------------PEPEPEPE--------REA 256
                          |:.|.                           .|||||||        |:|
  Fly    78 QLARRIWEETREIARAFPDVFTREEIAKSLARLGYGEFELPPEEEVMEPEPEPEQHLPLRYTRDA 142

Human   257 TPTPAPAAPEE--------------------------------------------PPAP---PEF 274
            :||...|.|.:                                            ||.|   ||
  Fly   143 SPTIIKAEPSDEEQFPLRNYNNNLLKSIAEYEDCMKMQNIKEEIPPIPSPQLFYPPPTPLAEPE- 206

Human   275 RCQVCGQSFTQSWFLKGHMR-------------------------------------KHKASFD- 301
                 ..|.||...|..:|.                                     |.|:|.|
  Fly   207 -----DLSVTQRRVLSENMNLQNVARALLSMQHMAPQHAPPPIDMEEDQENQDINQLKIKSSNDL 266

Human   302 -HACPVCGRCFKEPWFLKNHMKVHA---SKLGPLRAPGPASGPARAPQPPDLGLLAYE-----PL 357
             :.|..|.:|:.....|..|.:.||   ::...:|:           ||...|.:..:     ..
  Fly   267 YYQCQQCNKCYATYAGLVKHQQTHAYESTEYKIIRS-----------QPGGSGAIVDQTEFCTDQ 320

Human   358 GPALLLAPAPTPAERREPPSLLGYLSLRAGEGRPNGEGAEPGPGRSFGGFRPLSSALPARARRHR 422
            ..||:.|.....|:..:.|         .|..|.:.:..    |:|:..:..||        :|:
  Fly   321 ASALIQAANVASAQSMQKP---------VGVPRYHCQDC----GKSYSTYSGLS--------KHQ 364

Human   423 -----AEEPEEEEEVVEAE--EETWARGRSLGSLASLHPRPGEGPGHSASAAGAQARSTATQEEN 480
                 :.|..:.::|...:  ::|:.   |||:| .:|.|.     |:...
  Fly   365 QFHCPSAEGNQVKKVFSCKNCDKTYV---SLGAL-KMHIRT-----HTLPC-------------- 406

Human   481 GLLVGGTRPEGGRGATGKDCPFCGKSFRSAHHLKVHLRVHTGERPYKCPHCDYAGTQSGSLKYHL 545
                              .||.|||:|.....|:.|:|.||||:|:.|.||:.|.....:|:.|:
  Fly   407 ------------------KCPICGKAFSRPWLLQGHIRTHTGEKPFSCQHCNRAFADRSNLRAHM 453

Human   546 QRHHREQRSGAGPGPPPEPPPPSQRGSAPQSGAKPSPQPATWVEGASSPRPPSSGAGPGSRRKPA 610
            |.|                                     :.|:..|.|....|.:      :.:
  Fly   454 QTH-------------------------------------SDVKKYSCPTCTKSFS------RMS 475

Human   611 SPGRTLRNGRGGEAEPLDLSLRAGPGGEAGPGGALHRCLFCPFATGAPELMALHLQVHHSRRARG 675
            ...:.|::|...|..          ||.:|.||...:           :.:..||||:.    .|
  Fly   476 LLAKHLQSGCQTEQS----------GGPSGSGGGFDQ-----------QQLQQHLQVYE----EG 515

Human   676 RRPPQADASPPYARVPSGETPPSPSQEGEEGSGLSRP 712
            ..|.|.    .||    |....|..:|.|.|....:|
  Fly   516 HNPHQL----YYA----GSVGSSNGEEEEGGEYQMQP 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZNF219	NP_057507.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		RPC10	53..>93	CDD:441599
		C2H2 Zn finger	59..79	CDD:275368
		zf-C2H2	85..107	CDD:395048
		C2H2 Zn finger	87..107	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	137..160
		C2H2 Zn finger	165..183	CDD:275368
		C2H2 Zn finger	191..207	CDD:275368	4/8 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	215..275		33/177 (19%)
		zf-C2H2	274..296	CDD:395048	5/58 (9%)
		C2H2 Zn finger	276..296	CDD:275368	5/56 (9%)
		zf-C2H2	302..324	CDD:395048	5/21 (24%)
		C2H2 Zn finger	304..324	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	384..495		17/117 (15%)
		PTZ00449	<453..>612	CDD:185628	29/158 (18%)
		C2H2 Zn finger	500..520	CDD:275368	9/19 (47%)
		zf-C2H2	500..520	CDD:395048	9/19 (47%)
		zf-H2C2_2	512..537	CDD:463886	12/24 (50%)
		C2H2 Zn finger	528..548	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	542..648		15/105 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	668..722		11/45 (24%)
wor	NP_476601.1	C2H2 Zn finger	270..290	CDD:275368	5/19 (26%)
		C2H2 Zn finger	317..334	CDD:275368	3/16 (19%)
		zf-C2H2	345..367	CDD:395048	5/33 (15%)
		C2H2 Zn finger	347..367	CDD:275368	5/31 (16%)
		zf-C2H2	380..402	CDD:395048	7/30 (23%)
		C2H2 Zn finger	382..402	CDD:275368	7/28 (25%)
		zf-C2H2	406..428	CDD:395048	9/53 (17%)
		C2H2 Zn finger	408..428	CDD:275368	9/19 (47%)
		zf-C2H2	434..456	CDD:395048	7/21 (33%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	464..481	CDD:275368	2/22 (9%)