Protein Alignment ZNF219 and CG2889

DIOPT Version :10

• Sequence 1: NP_057507.2
• Gene: ZNF219 / 51222
• HGNCID: 13011
• Length: 722
• Species: Homo sapiens
• Sequence 2: NP_572632.1
• Gene: CG2889 / 31977
• FlyBaseID: FBgn0030206
• Length: 581
• Species: Drosophila melanogaster
• Alignment Length: 506
• Identity: 82/506 - (16%)
• Similarity: 133/506 - (26%)
• Gaps: 248/506 - (49%)

Human    54 ERRFPCPVCGKRFRFNSILALHLRAHPGAQAFQCPHCGHRAAQRALLRSHLRT-HQPERPRSPAA 117
            :|.:....|||.|...|.|..|:|.|...:.|.|..|......:..|.:|:.| |.
  Fly   298 QREYYIKCCGKVFTRASKLMDHIRKHINPKLFTCTICKKSLNSQDYLATHIETVHN--------- 353

Human   118 RLLLELEERALLREARLGRARSSGGMQATPATEGLARPQAPSSSAFRCPYCKGKFRTSAERERHL 182
                        :.|::|:...                       |.||.|:..|  |:||....
  Fly   354 ------------KVAQIGKVLK-----------------------FPCPKCERTF--SSERRMAN 381

Human   183 HILHRPWKCGLCSFGSSQEEELLHHSLTAHGAPERPLAATSAAPPPQPQPQPPPQPEPRSVPQPE 247
            |:             :..:.:.|.|:
  Fly   382 HL-------------AKHDTDQLEHT--------------------------------------- 394

Human   248 PEPEPEREATPTPAPAAPEEPPAPPEFRCQVCGQSFTQSWFLKGHMRK-HKASFDHACPVCGRCF 311
                                        |::|.:||.....|:.|::. |:....|.|.:||:.|
  Fly   395 ----------------------------CEICCKSFANVHRLRRHIQSIHEDLHRHVCDICGKKF 431

Human   312 K-EPWFLKNHMKVHASKLGPLRAPGPASGPARAPQPPDLGLLAYEPLGPALLLAPAPTPAERREP 375
            | :|.| :.|:..|..                                   ::|||.      |.
  Fly   432 KFKPSF-ERHLLEHQG-----------------------------------VVAPAV------EC 454

Human   376 PSLLGYL----SLRAGEGRPNGEGAEPGPGRSFGGFRPLSSALPARARRHRAEEPEEEEEVVEAE 436
            |....:|    |||.                                  ||......:......
  Fly   455 PICRVWLKNEHSLRL----------------------------------HRFTHDSTDTVCPHC- 484

Human   437 EETWARGRSLGSLASLHPRPGEGPGHSASAAGAQARSTATQEENGLLVGGTRPEGGRGATGKDCP 501
                  |::..|..:|.       ||...|                         .:..|...|.
  Fly   485 ------GKTCTSRTALR-------GHVKYA-------------------------HKLTTNLQCT 511

Human   502 FCGKSFRSAHHLKVHLRVHTGERPYKCPHCDYAGTQSGSLKYHLQRHHREQ 552
            ||.|:|:...:|..|:.:|||.:.|.||||........::..|:::.|.::
  Fly   512 FCEKTFKQQRNLDEHMAIHTGLQLYNCPHCPKECRSRSNMYVHIKQRHADE 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZNF219	NP_057507.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		RPC10	53..>93	CDD:441599	13/38 (34%)
		C2H2 Zn finger	59..79	CDD:275368	8/19 (42%)
		zf-C2H2	85..107	CDD:395048	6/22 (27%)
		C2H2 Zn finger	87..107	CDD:275368	5/20 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	137..160		0/22 (0%)
		C2H2 Zn finger	165..183	CDD:275368	7/17 (41%)
		C2H2 Zn finger	191..207	CDD:275368	1/15 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	215..275		0/59 (0%)
		zf-C2H2	274..296	CDD:395048	6/22 (27%)
		C2H2 Zn finger	276..296	CDD:275368	6/20 (30%)
		zf-C2H2	302..324	CDD:395048	9/22 (41%)
		C2H2 Zn finger	304..324	CDD:275368	8/20 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	384..495		10/110 (9%)
		PTZ00449	<453..>612	CDD:185628	21/100 (21%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		zf-C2H2	500..520	CDD:395048	7/19 (37%)
		zf-H2C2_2	512..537	CDD:463886	10/24 (42%)
		C2H2 Zn finger	528..548	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	542..648		2/11 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	668..722
CG2889	NP_572632.1	zf-AD	2..79	CDD:214871
		BNR_2	<214..>290	CDD:463781
		C2H2 Zn finger	276..297	CDD:275368
		SUF4-like	301..>353	CDD:411020	15/51 (29%)
		C2H2 Zn finger	301..323	CDD:411020	8/21 (38%)
		C2H2 Zn finger	306..323	CDD:275368	8/16 (50%)
		C2H2 Zn finger	331..352	CDD:411020	5/20 (25%)
		C2H2 Zn finger	331..352	CDD:275368	5/20 (25%)
		C2H2 Zn finger	366..386	CDD:275368	8/34 (24%)
		C2H2 Zn finger	395..416	CDD:275368	6/20 (30%)
		C2H2 Zn finger	424..444	CDD:275368	8/20 (40%)
		C2H2 Zn finger	481..502	CDD:275368	6/59 (10%)
		C2H2 Zn finger	510..530	CDD:275368	7/19 (37%)
		C2H2 Zn finger	538..556	CDD:275368	5/17 (29%)