Protein Alignment ZNF219 and CG18262

DIOPT Version :10

• Sequence 1: NP_057507.2
• Gene: ZNF219 / 51222
• HGNCID: 13011
• Length: 722
• Species: Homo sapiens
• Sequence 2: NP_572453.1
• Gene: CG18262 / 31745
• FlyBaseID: FBgn0030012
• Length: 469
• Species: Drosophila melanogaster
• Alignment Length: 514
• Identity: 87/514 - (16%)
• Similarity: 125/514 - (24%)
• Gaps: 251/514 - (48%)

Human    85 FQCPHCGHRAAQRALLRSHLRTHQPERPRSPAARLLLELEERALLREARLGRARSSGGMQATPAT 149
            |||..|......:..|:||                            .||..:.::||.....|:
  Fly   172 FQCDQCDRAYNTKRSLQSH----------------------------RRLKHSEANGGSLDKSAS 208

Human   150 EGLARPQAPSSSAFRC--PYCKGKFRTSAERERHLHILHRPWKCGLCSFGSSQEEELLHHSLTAH 212
            |..::.:......::|  ..|...|||..:...|      .||               |..:.
  Fly   209 ERNSKKRKGPPKVYKCNEEACNQTFRTERDLRGH------RWK---------------HTGIF-- 250

Human   213 GAPERPLAATSAAPPPQPQPQPPPQPEPRSVPQPEPEPEPEREATPTPAPAAPEEPPAPPEFRCQ 277
                                                                           |.
  Fly   251 ---------------------------------------------------------------CD 252

Human   278 VCGQSFTQSWFLKGHMRKHKASFDHACPVCGRCFKEPWFLKNHMKVHASKLGPLRAPGPASGPAR 342
            :||:.||||..:..|.::|.....|.||.|...|.....|.:|...|..::
  Fly   253 ICGKPFTQSGNMMRHRQRHSGIKPHKCPECDATFYTQKELSSHSICHTGRM-------------- 303

Human   343 APQPPDLGLLAYEPLGPALLLAPAPTPAERREPPSLLGYLSLRAGEGRPNGEGAEPGPGRSFGGF 407
                                             |.:....      |||..:
  Fly   304 ---------------------------------PCICEVC------GRPCRD------------- 316

Human   408 RPLSSALPARARRHRAEEPEEEEEVVEAEEETWARGRSLGSLASLHPRPGEGPGHSASAAGAQAR 472
               ...|.|..|||..|.|.:.|          ..|::..|...|:.       |:.|..
  Fly   317 ---RGVLTAHMRRHTGERPAKCE----------VCGKAFYSFHDLNV-------HAVSHT----- 356

Human   473 STATQEENGLLVGGTRPEGGRGATGKDCPFCGKSFRSAHHLKVHLRVHTGERPYKCPHCDYAGTQ 537
                         ..||        ..|..||.:|:....|:||..:|:.:|.|.|..|.....|
  Fly   357 -------------NLRP--------FVCDVCGSTFQRKKALRVHKLLHSEQRKYACKLCGKTFAQ 400

Human   538 SGSLKYHLQRHHREQRSGAGPGPPPEPPPPSQRGSAPQSGAKPSPQPAT--WVEGASSP 594
            ||.|..|::.|...:..||                     .||.||..|  .:||.|.|
  Fly   401 SGGLNAHMRSHDPARVKGA---------------------VKPLPQSVTIEVIEGKSPP 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZNF219	NP_057507.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		RPC10	53..>93	CDD:441599	4/7 (57%)
		C2H2 Zn finger	59..79	CDD:275368
		zf-C2H2	85..107	CDD:395048	7/21 (33%)
		C2H2 Zn finger	87..107	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	137..160		4/22 (18%)
		C2H2 Zn finger	165..183	CDD:275368	6/19 (32%)
		C2H2 Zn finger	191..207	CDD:275368	0/15 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	215..275		0/59 (0%)
		zf-C2H2	274..296	CDD:395048	8/21 (38%)
		C2H2 Zn finger	276..296	CDD:275368	8/19 (42%)
		zf-C2H2	302..324	CDD:395048	7/21 (33%)
		C2H2 Zn finger	304..324	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	384..495		18/110 (16%)
		PTZ00449	<453..>612	CDD:185628	33/144 (23%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		zf-C2H2	500..520	CDD:395048	7/19 (37%)
		zf-H2C2_2	512..537	CDD:463886	8/24 (33%)
		C2H2 Zn finger	528..548	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	542..648		13/55 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	668..722
CG18262	NP_572453.1	COG5236	<222..>313	CDD:227561	28/229 (12%)
		C2H2 Zn finger	224..246	CDD:275368	8/42 (19%)
		C2H2 Zn finger	251..271	CDD:275368	8/19 (42%)
		zf-H2C2_2	263..288	CDD:463886	7/24 (29%)
		C2H2 Zn finger	279..327	CDD:275368	14/116 (12%)
		zf-H2C2_2	320..342	CDD:463886	9/31 (29%)
		C2H2 Zn finger	335..355	CDD:275368	5/36 (14%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		zf-C2H2	389..411	CDD:395048	8/21 (38%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)