Protein Alignment ZNF219 and rst2

DIOPT Version :10

• Sequence 1: NP_057507.2
• Gene: ZNF219 / 51222
• HGNCID: 13011
• Length: 722
• Species: Homo sapiens
• Sequence 2: NP_593288.1
• Gene: rst2 / 2543031
• PomBaseID: SPAC6F12.02
• Length: 567
• Species: Schizosaccharomyces pombe
• Alignment Length: 299
• Identity: 60/299 - (20%)
• Similarity: 93/299 - (31%)
• Gaps: 90/299 - (30%)

Human   433 VEAEEETWARGRSLGSLASLHPRPGEGPGHSASAAGAQARSTATQEENGLLVGGTRPEGGRGATG 497
            :.::..|.:..:...:|.|::...|....::.|:                :...::|.....|..
pombe     9 IASKANTLSESKVSENLMSINSDSGTSNANTPSS----------------VTSNSKPVASSTAAK 57

Human   498 KD------------CPFCGKSFRSAHHLKVHLRVHTGERPYKCPHCDYAGTQSGS-------LKY 543
            ||            |..|.::|....|||.|:|.||.|:|:.|...|...|..|.       |..
pombe    58 KDPNAPPQKVKQYVCETCTRAFARLEHLKRHIRSHTNEKPFTCSEIDGLPTGCGRQFSRRDLLLR 122

Human   544 HLQRHHREQRSGAGPGPPPEPPPPSQRGSAPQSGAKPSPQPATWVEGASSPRPPSSGAGPGSRRK 608
            |.|:.||            .|.|..:|.|.                 .:.|.|..|.....:...
pombe   123 HQQKIHR------------NPQPRRRRRST-----------------TALPNPSLSNVSVSTTNL 158

Human   609 PASPGRTLRNGRGGEAEPLDLSLRAGPGGEAGPGGALHRCLFCPFATGAPELMALHLQVHHSR-- 671
            .:.|..:|     .:|:.:| ..|.         ..||..|....|..:....|..||....|
pombe   159 ASKPVISL-----PQADSID-KFRY---------PKLHAALQAQLANNSGSFSASWLQAQQQRLV 208

Human   672 -RARGRRPPQADASPPYARVPSGETPPSPSQEGEEGSGL 709
             ...||....|.|        ||...|:.||..::..|:
pombe   209 SAGNGRETVNASA--------SGAVNPTSSQWSDQRLGV 239

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZNF219	NP_057507.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		RPC10	53..>93	CDD:441599
		C2H2 Zn finger	59..79	CDD:275368
		zf-C2H2	85..107	CDD:395048
		C2H2 Zn finger	87..107	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	137..160
		C2H2 Zn finger	165..183	CDD:275368
		C2H2 Zn finger	191..207	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	215..275
		zf-C2H2	274..296	CDD:395048
		C2H2 Zn finger	276..296	CDD:275368
		zf-C2H2	302..324	CDD:395048
		C2H2 Zn finger	304..324	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	384..495		6/61 (10%)
		PTZ00449	<453..>612	CDD:185628	34/177 (19%)
		C2H2 Zn finger	500..520	CDD:275368	8/19 (42%)
		zf-C2H2	500..520	CDD:395048	8/19 (42%)
		zf-H2C2_2	512..537	CDD:463886	11/24 (46%)
		C2H2 Zn finger	528..548	CDD:275368	7/26 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	542..648		18/105 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	668..722		11/45 (24%)
rst2	NP_593288.1	COG5048	37..547	CDD:227381	56/271 (21%)
		C2H2 Zn finger	72..92	CDD:275368	8/19 (42%)
		C2H2 Zn finger	100..128	CDD:275368	7/27 (26%)