Protein Alignment ZNF219 and let-391

DIOPT Version :10

• Sequence 1: NP_057507.2
• Gene: ZNF219 / 51222
• HGNCID: 13011
• Length: 722
• Species: Homo sapiens
• Sequence 2: NP_491744.3
• Gene: let-391 / 182953
• WormBaseID: WBGene00006492
• Length: 453
• Species: Caenorhabditis elegans
• Alignment Length: 366
• Identity: 74/366 - (20%)
• Similarity: 116/366 - (31%)
• Gaps: 122/366 - (33%)

Human   244 PQPEPEPEPEREATPTPAPAAPEE---PPAPPEFRCQVCGQSFTQSWFLKGHMRKHKASFDHACP 305
            |..:.|.|...|....|.....::   ...|....|:|||.:......:..|||.|.....:.|.
 Worm    24 PDAQKEHEELEEIVKIPDSTYRKKKGNQKLPTVTTCEVCGVALKYPSRIMEHMRTHTGEKPYECD 88

Human   306 VCGRCFKEPWFLKNHMKV-HASKL--------------------------GPLRAPGPASGPARA 343
            :||..|.:...:.||.:| |...|                          |..||     ||||.
 Worm    89 ICGMRFTQRTPMINHFRVQHMGDLPFLCNFGCGKRFVNNSRRTAHELSHNGLKRA-----GPARP 148

Human   344 PQPP---------DLGLLAYEPLGPALLLAPAPTPAERREPPSLLGYLSLRAGEGRPNGEGAEPG 399
            ...|         |:.:|:...|            |....||::....     :..|:...:.|.
 Worm   149 YLKPVKKIVCPSMDMDILSNSAL------------ANYISPPTIDSIF-----QSDPSTSSSSPS 196

Human   400 PGRS---------FGGFRPLSSALPARAR--------RHRAEEPEEEEEVVEAEEETWARGRSLG 447
            ..:|         :...:.:..|..:.||        ..|...|.:||..:|
 Worm   197 QFQSSNQTTKQSIYPSEKEMEKAAISNARIDDVINTVLARVLAPIDEEIPIE------------- 248

Human   448 SLASLHPRPGEGPGHSASAAGAQARSTATQEENGLLVGGTRPEGGRGATGKDCPFCGKSFRSAHH 512
                   .|.:.|         |.|:..:               .|.||...|..||...:....
 Worm   249 -------EPEKAP---------QKRAYIS---------------NRRATLAQCNICGLMLKHPSK 282

Human   513 LKVHLRVHTGERPYKCPHCDYAGTQSGSLKYHLQRHHREQR 553
            :..|:|.||||:|::|..|..:.:::.|||.|::|.|..:|
 Worm   283 IADHIRTHTGEKPFECGECGLSLSKASSLKVHIRRMHTGER 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZNF219	NP_057507.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		RPC10	53..>93	CDD:441599
		C2H2 Zn finger	59..79	CDD:275368
		zf-C2H2	85..107	CDD:395048
		C2H2 Zn finger	87..107	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	137..160
		C2H2 Zn finger	165..183	CDD:275368
		C2H2 Zn finger	191..207	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	215..275		6/33 (18%)
		zf-C2H2	274..296	CDD:395048	7/21 (33%)
		C2H2 Zn finger	276..296	CDD:275368	7/19 (37%)
		zf-C2H2	302..324	CDD:395048	7/22 (32%)
		C2H2 Zn finger	304..324	CDD:275368	7/20 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	384..495		16/127 (13%)
		PTZ00449	<453..>612	CDD:185628	26/101 (26%)
		C2H2 Zn finger	500..520	CDD:275368	5/19 (26%)
		zf-C2H2	500..520	CDD:395048	5/19 (26%)
		zf-H2C2_2	512..537	CDD:463886	9/24 (38%)
		C2H2 Zn finger	528..548	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	542..648		5/12 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	668..722
let-391	NP_491744.3	C2H2 Zn finger	357..377	CDD:275368
		C2H2 Zn finger	59..79	CDD:275368	7/19 (37%)
		zf-H2C2_2	73..96	CDD:463886	8/22 (36%)
		C2H2 Zn finger	87..108	CDD:275368	7/20 (35%)
		C2H2 Zn finger	116..137	CDD:275368	0/20 (0%)
		C2H2 Zn finger	270..290	CDD:275368	5/19 (26%)
		zf-H2C2_2	286..>302	CDD:463886	8/15 (53%)
		C2H2 Zn finger	298..319	CDD:275368	7/20 (35%)
		C2H2 Zn finger	327..347	CDD:275368