DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PCSK1 and Fur1

DIOPT Version :10

Sequence 1:NP_000430.3 Gene:PCSK1 / 5122 HGNCID:8743 Length:753 Species:Homo sapiens
Sequence 2:NP_001262954.1 Gene:Fur1 / 47220 FlyBaseID:FBgn0004509 Length:1478 Species:Drosophila melanogaster


Alignment Length:686 Identity:316/686 - (46%)
Similarity:413/686 - (60%) Gaps:74/686 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    31 FVNEWAAEIPGGPEA-ASAIAEELGYDLLGQIGSLENHYLFKHKNHPRRSRRSAFHITKRLSDDD 94
            :.:.||..||.|... |.|:|::.|:..||:|  .::||.|.|....:||...|.|...||.|||
  Fly   231 YTHTWAVHIPNGDNGMADAVAKDHGFVNLGKI--FDDHYHFAHHKVSKRSLSPATHHQTRLDDDD 293

Human    95 RVIWAEQQYEKERSKRSALR-------DSALNL-----FNDPMWNQQWYLQDTRMTAALPKLDLH 147
            ||.||:||..|.||||..:|       ..|:::     |||..|.|.|||...      ..||::
  Fly   294 RVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRG------GGLDMN 352

Human   148 VIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRC 212
            |||.|:.||||||||:|:||||||.:|.||..||||:||||.|.:|.||.|.||.|:.|:|||||
  Fly   353 VIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRC 417

Human   213 AGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTV 277
            |||:|..|||..|.||:||.:.|||:|||||.||||:||.|:..||.|:|||||||||:||||||
  Fly   418 AGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTV 482

Human   278 EGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPW 342
            :|||.||.:||..|..:||.||||||:||||||||:.|||:|||||:||:|:|||||:::|..||
  Fly   483 DGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPW 547

Human   343 YAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDM 407
            |:|||||||||:||||...::::.:.|||:.||.:||||||||||||||.||.|::|.||||||:
  Fly   548 YSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDL 612

Human   408 QHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVK-- 470
            ||:||.|::...| .:|.|.:||.|..|:..||:||::|..:|.:|  |.|::|||::.|.:.  
  Fly   613 QHIVVRTAKPANL-KDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVA--RNWKAVPEQQRCEINAP 674

Human   471 --DNDFEPRALKANGEVIIEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTST 533
              |....||.     .:.:::....|    .::..|||||.:.|:...||||:.:.|.|.|.||.
  Fly   675 HVDKVIPPRT-----HITLQLTVNHC----RSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSV 730

Human   534 VLLAERERDTSPNGFKNWDFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIV------NWKLILH 592
            .||..|..|.|.:||..|.|||||||||:|.|.|.|       .|.||||.:      .|.||.:
  Fly   731 TLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQL-------EIHNEGRYMGHALLREWSLIFY 788

Human   593 GTSSQPEHMKQPRVYTSYNTVQNDRRGVEKMVDPGEEQPTQENPKENTLVSKSP----------S 647
            ||:.              :...||...|.|........|...:...|...:.||          .
  Fly   789 GTTQ--------------SIGPNDPISVPKPSGSEATTPNSSSTTSNLHQAYSPQYPRIPPNNFG 839

Human   648 SSSVGGRRDELEEGAPSQAMLRLLQSAFSKNSPPKQ 683
            ||..||.:..|.:..|......:..:....::||||
  Fly   840 SSPSGGSKLPLGKVPPPNKSSYVTNNPLLNSAPPKQ 875

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PCSK1NP_000430.3 S8_pro-domain 34..110 CDD:465126 34/76 (45%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 121..415 CDD:173789 189/293 (65%)
P_proprotein 504..591 CDD:460225 43/92 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 596..662 13/75 (17%)
Proho_convert 713..751 CDD:463483
Fur1NP_001262954.1 S8_pro-domain 234..309 CDD:465126 34/76 (45%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 332..621 CDD:173789 190/294 (65%)
P_proprotein 701..787 CDD:460225 43/92 (47%)
FU 1320..>1350 CDD:214589
Blue background indicates that the domain is not in the aligned region.

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