Protein Alignment PCSK1 and S1P

DIOPT Version :10

• Sequence 1: NP_000430.3
• Gene: PCSK1 / 5122
• HGNCID: 8743
• Length: 753
• Species: Homo sapiens
• Sequence 2: NP_649337.2
• Gene: S1P / 40399
• FlyBaseID: FBgn0037105
• Length: 1012
• Species: Drosophila melanogaster
• Alignment Length: 278
• Identity: 63/278 - (22%)
• Similarity: 103/278 - (37%)
• Gaps: 73/278 - (26%)

Human   146 LHVIPVWQKGITGKGVVITVLDDGLEWNHTDI-----YANYDPEASYDFNDNDHDPFPRYDPTNE 205
            ||...:|:.|||||||.:.:.|.||..||...     ..|:..|.|.|               :.
  Fly   148 LHANILWKLGITGKGVKVAIFDTGLTKNHPHFRNVKERTNWTNEKSLD---------------DR 197

Human   206 NKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYS----- 265
            ..|||..||.|   |::.:| :|.|.::        |..:......|.:.:....:|.::
  Fly   198 VSHGTFVAGVI---ASSREC-LGFAPDA--------DLYIFKVFTNSQVSYTSWFLDAFNYAIYR 250

Human   266 -------ASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGG-------RQGDN 316
                   :..||:    .::.|  ..:|..|.      .....|.:.|:||.|       ..||.
  Fly   251 KINILNLSIGGPD----FMDSP--FVEKVLEL------SANNVIMISAAGNDGPLYGTLNNPGDQ 303

Human   317 CDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLA---TSYSSGDYTDQRITSADLHNDCTETH 378
            .|..|.....:...|:..|.:|::.|........:.   .:|.|      ::..:|:...|...
  Fly   304 SDVVGVGGIQFDDKIAKFSSRGMTTWELPLGYGRMGLDIVTYGS------QVEGSDVRKGCRRL- 361

Human   379 TGTSASAPLAAGIFALAL 396
            :|||.|:|:.||..||.:
  Fly   362 SGTSVSSPVVAGAAALLI 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PCSK1	NP_000430.3	S8_pro-domain	34..110	CDD:465126
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	121..415	CDD:173789	63/278 (23%)
		P_proprotein	504..591	CDD:460225
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	596..662
		Proho_convert	713..751	CDD:463483
S1P	NP_649337.2	Peptidases_S8_SKI-1_like	154..407	CDD:173805	61/272 (22%)
		DUF4350	610..754	CDD:464118