DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PCSK1 and Fur2

DIOPT Version :9

Sequence 1:	NP_000430.3	Gene:	PCSK1 / 5122	HGNCID:	8743	Length:	753	Species:	Homo sapiens
Sequence 2:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster

Alignment Length:	714	Identity:	316/714 - (44%)
Similarity:	424/714 - (59%)	Gaps:	90/714 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     1 MERRAWSLQCTAFVLFCAWCALNSAKAKRQFVNEWAAEIPGGPEAASAIAEELGYDLLGQIGSLE 65
            :||::.||......:|.|:    |...:..:.||:|..||.|.:.|..||.:.|:...||||||:
  Fly   213 VERQSNSLDFDGVDMFGAF----SIPEEAIYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLD 273

Human    66 NHYLFKHKNHPRRSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSA------------------ 112
            |:|||:|.:..:||.||:......|..::.|.|.:||:||.|.||..
  Fly   274 NYYLFQHHHVSKRSLRSSRKHQGALKSENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHG 338

Human   113 ---------------------------LRD-SALNLFNDPMWNQQWYLQDTRMTAALPKLDLHVI 149
                                       .|| |:..:|.||::.:||||. ::...|...||::|.
  Fly   339 GYVVDPNPHLSFSPESISLASHSQRMEYRDVSSHFIFPDPLFKEQWYLV-SKNGGAKDGLDMNVG 402

Human   150 PVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAG 214
            |.||||.||||||:::||||::.||.|:..|||||||:|.|.||.||.|:  ...:|||||||||
  Fly   403 PAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAG 465

Human   215 EIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEG 279
            |:|..|.|:.||||||||:.:||:|||||.|.|.:||.::..||.|:|||||||||.|||.||:|
  Fly   466 EVAAVAFNNFCGVGVAYNASIGGVRMLDGKVNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDG 530

Human   280 PGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYA 344
            ||.||::||.|||..||||||||||||||||||..|:|:|||||:||:|:|||||:|.|..|||.
  Fly   531 PGPLARRAFIYGVTSGRQGKGSIFVWASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYL 595

Human   345 EKCSSTLATSYSSG-DYTDQRITSADLHND------CTETHTGTSASAPLAAGIFALALEANPNL 402
            |:|||||||:|||| ...|:.:.:.|:...      ||..||||||||||||||.||||||||.|
  Fly   596 EECSSTLATTYSSGTPGHDKSVATVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPEL 660

Human   403 TWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKEC 467
            ||||||:|||:||...||....||..||.....:.:||:||::|.|:|.||:  .|.|||.:..|
  Fly   661 TWRDMQYLVVYTSRPAPLEKENGWTLNGVKRKYSHKFGYGLMDAGAMVSLAE--QWTSVPPQHIC 723

Human   468 VVKDNDFEPRALKANGEVI-IEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGT 531
            ..::|:.:.:...|.|..: ..:....|.|..|.::.|||||...|:.:..||:|.:.|||..||
  Fly   724 KSRENNEDRKIDGAYGSTLSTHMDVNGCAGTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGT 788

Human   532 STVLLAERERDTSPNGFKNWDFMSVHTWGENPIGTWTLRITDMSG---RIQNEGRIVNWKLILHG 593
            ::.||.||.||...:.|.:|.|:|||.|||...|.|||::  ::|   |:...|.:..|:||.:|
  Fly   789 TSTLLFERPRDIVKSNFDDWPFLSVHFWGEKAEGRWTLQV--INGGRRRVNQPGILSKWQLIFYG 851

Human   594 TSSQPEHMKQPRVYTSYNTVQNDRRGVEKMVDPGEEQPTQENPKENTLVSKSPSSSSVGGRRDE 657
            ||:||..:|...:.:|                |....|:..||      ...||:|::|...:|
  Fly   852 TSTQPMRLKSELLNSS----------------PQLRSPSSSNP------FLFPSASNIGQPANE 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PCSK1	NP_000430.3	S8_pro-domain	34..110	CDD:293079	32/75 (43%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	121..415	CDD:173789	188/300 (63%)
		Peptidase_S8	158..432	CDD:278510	179/280 (64%)
		P_proprotein	504..591	CDD:279782	38/89 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..662		13/62 (21%)
		Proho_convert	715..751	CDD:288988
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	32/75 (43%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	189/301 (63%)
		Peptidase_S8	411..700	CDD:278510	181/290 (62%)
		P_proprotein	761..849	CDD:279782	38/89 (43%)
		Furin-like	966..1126	CDD:279142
		FU	970..1013	CDD:238021
		FU	1017..1067	CDD:238021
		FU	1063..1106	CDD:214589
		GF_recep_IV	1068..1232	CDD:291509
		FU	1116..1163	CDD:238021
		FU	1211..1255	CDD:214589
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720