Protein Alignment CPA4 and CG4408

DIOPT Version :10

• Sequence 1: NP_057436.2
• Gene: CPA4 / 51200
• HGNCID: 15740
• Length: 421
• Species: Homo sapiens
• Sequence 2: NP_651141.2
• Gene: CG4408 / 42762
• FlyBaseID: FBgn0039073
• Length: 479
• Species: Drosophila melanogaster
• Alignment Length: 451
• Identity: 129/451 - (28%)
• Similarity: 224/451 - (49%)
• Gaps: 56/451 - (12%)

Human     3 WILFIGALIGSSIC-----------------------------GQEKFFGDQVLRINVRNGDEIS 38
            |:|.   |:.||:|                             .|.::...::.::.:.:.:.:
  Fly    37 WLLL---LLVSSVCVIQESKASSFCTKADQCALDEEIKTAADSVQARYDHTRIYQVELASEEHV- 97

Human    39 KLSQLVNSNNLKLNFWKSPSSFNRPVDVLVPSVSLQAFKSFLRSQGLEYAVTIEDLQALLDNEDD 103
            :|.|.:...:...:|........:.:.::|....:..|...:.|..:.:.|...:.|||:|....
  Fly    98 RLFQALEQASDSCSFMGHARQPGQKLTIMVTGAKVADFDDLVHSYNVTHRVLNYNFQALIDANYL 162

Human   104 EMQHNEGQERSSNNFNYGAYHSLEAIYHEMDNIAADFPDLARRVKIGHSFENRPMYVLKFSTGKG 168
            |:   ..::.....|::..||.||:|...:..:|...|::. .|::|.|.:.||:..::.:. ..
  Fly   163 EV---APEDTKPEEFDWKRYHPLESINAWLKKLAETHPEVL-LVELGVSAQGRPILGVQIAF-DN 222

Human   169 VRRPAVWLNAGIHSREWISQATAIWTARKIVSDYQRDPAITSILEKMDIFLLPVANPDGYVYTQT 233
            ..|..|::.:|||:||||:.|||.:...::|:  .:|.|:.::......::.|..|||||.||..
  Fly   223 ENRTTVFVESGIHAREWIAPATATYIIDQLVN--SKDSAVQALARSQRWYIFPTVNPDGYQYTFK 285

Human   234 QNRLWRKTRSRNPGSSCIGADPNRN----WNASFAGKGASDNPCSEVYHGPHANSEVEVKSVVDF 294
            .:|:|||.|:.  ...|.|.|.|||    ||.:    |||.:||...|.||.|.||||.:.:::|
  Fly   286 GDRMWRKNRAL--FGICRGVDLNRNFPFHWNVT----GASGDPCRYDYSGPSAASEVETQRMIEF 344

Human   295 IQ---KHGNFKGFIDLHSYSQLLMYPYGYSVKKAPDAEELDKVARLAAKALASVSGTEYQVGPTC 356
            |:   :....:.||.||||||::|:|||:|.::..:..:|..:.:|||..:..|||..|:.|...
  Fly   345 IRHRVESERIRTFISLHSYSQMIMFPYGHSAERVDNYHDLTDIGKLAANKIKDVSGRIYKSGSIY 409

Human   357 TTVYPASGSSIDWAYDN-GIKFAFTFELRDTGTYG--FLLPANQIIPTAEETWLGLKTIME 414
            .|:||:||.|.|||:.. .|...|::|||......  |:|.|.:|.|||.|.:..::||::
  Fly   410 ETIYPSSGGSKDWAHGQLKIPITFSYELRGPADSEDLFILSAKEIEPTAAEAFASIQTIVQ 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CPA4	NP_057436.2	Propep_M14	27..101	CDD:460505	11/73 (15%)
		M14_CPA	118..419	CDD:349442	110/307 (36%)
CG4408	NP_651141.2	Propep_M14	87..159	CDD:460505	10/72 (14%)
		M14_CP_A-B_like	179..466	CDD:349433	107/296 (36%)