Protein Alignment NIN and Nin

DIOPT Version :10

• Sequence 1: XP_024305390.1
• Gene: NIN / 51199
• HGNCID: 14906
• Length: 2163
• Species: Homo sapiens
• Sequence 2: NP_001260093.1
• Gene: Nin / 33757
• FlyBaseID: FBgn0000228
• Length: 1118
• Species: Drosophila melanogaster
• Alignment Length: 1500
• Identity: 329/1500 - (21%)
• Similarity: 541/1500 - (36%)
• Gaps: 466/1500 - (31%)

Human     3 EVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQF 67
            ||..|.:|.:|.::|.|.:|. .|.|.::.|..||.:|.|.:....|..:|...:.|| |.|.||
  Fly     2 EVSADPYEQKLYQMFRSCETQ-CGLLDEKSLLKLCSLLELRDQGSALIASLGGSHQLG-VSFGQF 64

Human    68 KEALILILSRTLSNEEHFQEPASVGVSCQQVARVSGPLLNGHKLTHCLLIKDCS-LEAQPKYVRG 131
            ||||:..|.      ..|....|.|...:.:.....||.|    |:.....:.| .|..||.|.|
  Fly    65 KEALLNFLG------SEFDGNTSSGFIERSLVITDEPLNN----TYIESPPESSDREVSPKLVVG 119

Human   132 GKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRS----EEYEAEGQLR 192
            .|:|||||.|  |:.:.|. .||..:..||          |..:..:.|||    :|...:.| |
  Fly   120 TKKYGRRSRP--QQGIYEL-SVTDSDNTDE----------DQLQQQQNQRSLNGCDELGVQVQ-R 170

Human   193 FWNPDDLNASQ-------SGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVD 250
            ..:..||..|:       |||         ||:. |..|...|..:.|
  Fly   171 SSSQSDLPGSRRLRSVHTSGS---------KLKR-CASLPARRKMNSN----------------- 208

Human   251 GEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLK-----RHLSMQSFDESGRRT 310
                                       ..|.:.:|:|:...:||.     :|.|  |.:..|.|.
  Fly   209 ---------------------------TTGATTSPTAAAKLKQLSIQSQAQHSS--SVESLGHRL 244

Human   311 TTSSAMTST-----IGFRVFSCLDD-----GMGHASVERILDTWQEEGIENSQEILKALDFSLDG 365
            .|:.|.:|.     .|.| :||..|     .:...||..|::.|:...|.|::.:|..|.|..:.
  Fly   245 ATNPAPSSEHWRCYHGGR-WSCCKDTVTPQQLETISVHSIMEAWELASIPNTRNLLHVLGFDEEE 308

Human   366 NINLTELTLALENELLVTKNSIHQA----ALASFKA-EIRHLLERVDQVVREKEKLRSDLDKAEK 425
            .:||.:||.|||.||........|:    |||:.:| |:.:......|...|..|||:|...|.:
  Fly   309 EVNLQQLTKALEEELRGIDGDHEQSNMLRALAALQATELGNYRLAYRQQHEENLKLRADNKAANQ 373

Human   426 LKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIE 490
            ..:|:|.|||:.||::|..::..:::|::.:...:..:...:..:|:......||    ||.:::
  Fly   374 RVALLAVEVDERHASLEDNSKKQVQQLEQRHASMVREITLRMTNDRDHWTSMTGK----LEAQLK 434

Human   491 KAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAE 555
            ..:.||..:|..|.|...||:.||:|     ::.|..: :|..|::|:
  Fly   435 SLEQEEIRLRTELELVRTENTELESE-----QQKAHIQ-ITELLEQNI----------------- 476

Human   556 FFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 620
                                       :|..||.:                    .::|.|..||
  Fly   477 ---------------------------KLNQELAQ--------------------TSSSIGGTPE 494

Human   621 HGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMK 685
            |       :||             :.:.|.         |||
  Fly   495 H-------SPL-------------RPRRHS---------EDK----------------------- 507

Human   686 QRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHL--QEK 748
                      |:::..|..::|.||.:.|.|::...|.|.    |.:.|.|:|...||..  |||
  Fly   508 ----------EEEMLQLMEKLAALQMENAQLRDKTDELTI----EIESLNVELIRSKTKAKKQEK 558

Human   749 LRLQHEME-------------LKARLTQAQASFERER---EGLQSSAWTEEKVRGLTQELE--QF 795
            ...|.:.|             .|..||:......::|   ||.||.|........|..||:  |.
  Fly   559 QEKQEDQESAATATKRRGDSPSKTHLTEESPRLGKQRKCTEGEQSDASNSGDWLALNSELQRSQS 623

Human   796 HQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCE 860
            ..|:|||| .:...|.||           ||:..:|........|:.::|...: ..|:..|.||
  Fly   624 QDEELTSL-RQRVAELEE-----------ELKAAKEGRSLTPESRSKELETSLE-QMQRAYEDCE 675

Human   861 SALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQERE 925
            ...|:.....||    |.|::|:.....:.|.|:...|..|.....:|...::...|.:  .||:
  Fly   676 DYWQTKLSEERQ----LFEKERQIYEDEQHESDKKFTELMEKVREYEEQFSKDGRLSPI--DERD 734

Human   926 MLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA 990
            |||:.|.|                             |..:..:|:||..:.|.|:
  Fly   735 MLEQQYSE-----------------------------LEAEAAQLRSSSIQMLEEK--------- 761

Human   991 SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQA 1055
                 :|.:..|:.|.:..||.:...:    .|....||......|::|.|..:        ..|
  Fly   762 -----AQEISSLQSEIEDLRQRLGESV----EILTGACELTSESVAQLSAEAGK--------SPA 809

Human  1056 TSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGD-------VLLSLQRAHEQAVKENVK 1113
            :||:|.|               ...|.:|:..:.|.::.|       .||....:|:.|.:.|
  Fly   810 SSPISYL---------------WLQSTIQEPAKSLADSKDEATASAIELLGGSPSHKTASRNN-- 857

Human  1114 MATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEQFLQQNRTKQVEGVTRRHVLSDLE 1178
                                    |....|..|..|..::.   |...:....|.:..:..:.
  Fly   858 ------------------------LTTSETSIFSTTPFESS---QSGPSPTNSGNSNAYGANP-- 893

Human  1179 DDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCAD 1243
                   |....|..:|.: ..:::.||....::.|.|.....:|:|..::.|.|..:      .
  Fly   894 -------GPAPISKPKRSQ-SPQQAAASEGEIADCETSSTASGKSFESNSKTSCLSHE------K 944

Human  1244 CDRASEKKQDL----LFDVSVLKKKLK-----------MLERIPEASPKYKLLYEDVSRENDCLQ 1293
            |...|..|::|    .|::| ||:::|           .|:::.||.|..:..|...:  :..||
  Fly   945 CSSPSALKEELKRLKFFELS-LKEQIKDLSLQRDGLVMELQQLQEARPVLEKAYARTT--HPTLQ 1006

Human  1294 EELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEGLNVLVLRL 1358
            :.|..:|.|       |:       .||:.:|:.:..||:.  :::|:.:.::|   ||.|..|:
  Fly  1007 QRLNQLELR-------NR-------HLQNVIKQQQHYTESL--MQQSWRQHQVE---LNDLHSRI 1052

Human  1359 --QGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQEN 1421
              ||.:...|...:|..|..:.:..:||      .::....|.||:...||..:|.     :|:.
  Fly  1053 ETQGVLLADQTQRLQSADILVKDLYVEN------SHLTATVQRLEQQRARVNLIHQ-----QQQQ 1106

Human  1422 QYLEG 1426
            |.|.|
  Fly  1107 QRLVG 1111

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NIN	XP_024305390.1	SMC_prok_B	<437..855	CDD:274008	84/437 (19%)
		Smc	<686..>1233	CDD:440809	116/573 (20%)
		SMC_prok_B	<1462..>2125	CDD:274008
Nin	NP_001260093.1	Smc	<306..>775	CDD:440809	142/670 (21%)