Protein Alignment ZNF639 and NRG2

DIOPT Version :10

• Sequence 1: NP_057415.1
• Gene: ZNF639 / 51193
• HGNCID: 30950
• Length: 485
• Species: Homo sapiens
• Sequence 2: NP_009622.1
• Gene: NRG2 / 852358
• SGDID: S000000270
• Length: 220
• Species: Saccharomyces cerevisiae
• Alignment Length: 206
• Identity: 39/206 - (18%)
• Similarity: 79/206 - (38%)
• Gaps: 42/206 - (20%)

Human   107 IVICDEECDSPESVNQQTQEESPIEVHTAED-------------VPIAVEVHAISEDYDIETENN 158
            |:..|.:|:.|.:.     |.||.::....:             :|:....|.|.:|...:....
Yeast    13 ILAKDRKCEFPINF-----ECSPSQITLMPEMFSFNNERKYQTLIPLMKTSHLIDDDLKDKLNKC 72

Human   159 SSESLQ-DQTDEEPPAKLCKILDKSQALNVTAQQKWPLLRANSSGLYKCELCEFNSKYFSDLK-- 220
            :.:... .|.:......:.::....:...:...|...:::|.::|..|       |..:|.:|
Yeast    73 AFDFFSGKQANRTSDGTISRLTASGKTSPILPLQNINIVKAENTGNGK-------SDPYSSIKIS 130

Human   221 --QHMILKHKRTDSNV--------CRVCKESFSTNMLLIEHAKLHE-EDPYICKY--CDYKTVIF 272
              ...::|.|.|.:|.        |::|...|:|:..|..|.::|. |..:||.:  |..:....
Yeast   131 KPTKTVIKLKSTKTNTAGQRTRHFCKICSTGFTTSGHLSRHNRIHTGEKNHICPHEGCGQRFSRH 195

Human   273 ENLSQHIADTH 283
            :|.:||.. ||
Yeast   196 DNCNQHYR-TH 205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZNF639	NP_057415.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		C2H2 Zn finger	235..255	CDD:275368	6/19 (32%)
		C2H2 Zn finger	262..283	CDD:275368	5/22 (23%)
		C2H2 Zn finger	291..307	CDD:275368
		Interaction with CTNNA2. /evidence=ECO:0000269|PubMed:16182284	371..455
		C2H2 Zn finger	376..397	CDD:275368
		C2H2 Zn finger	405..425	CDD:275368
		C2H2 Zn finger	433..454	CDD:275368
		C2H2 Zn finger	462..482	CDD:275368
NRG2	NP_009622.1	COG5048	<72..>220	CDD:227381	28/142 (20%)
		C2H2 Zn finger	155..175	CDD:275368	6/19 (32%)
		C2H2 Zn finger	183..205	CDD:275368	5/22 (23%)