DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC5 and Herc4

DIOPT Version :9

Sequence 1:	XP_011530324.2	Gene:	HERC5 / 51191	HGNCID:	24368	Length:	1100	Species:	Homo sapiens
Sequence 2:	NP_084390.1	Gene:	Herc4 / 67345	MGIID:	1914595	Length:	1057	Species:	Mus musculus

Alignment Length:	1020	Identity:	344/1020 - (33%)
Similarity:	532/1020 - (52%)	Gaps:	146/1020 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   221 GAGVQVHQLLAGSGGARTPKCIKLG-----KNMK------------IHSVDQGAEHMLILSSDGK 268
            |.|::....:...|...|..|..||     |:.|            |.:|..|..|.|.|:..|:
Mouse    40 GCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVACGEAHTLALNDKGQ 104

Human   269 PFEYDNYSMKHLRFE------------SILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQL 321
            .:.:...|...|..:            ..|.:.:|:|:.||.||||||||..|:|.||||.:|||
Mouse   105 VYAWGLDSDGQLGLQGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQL 169

Human   322 GVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPS 386
            |:|......|:||:::.|.|:|..|::||.|||..|::||.|:.||:|:.|||||.....:..|:
Mouse   170 GLGIDCQKQTSPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPN 234

Human   387 LIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQI 451
            |::.|.:||:.::.||..|:|.||::|.:||||||.:||||||||.:|:.|..|.||:|..|||:
Mouse   235 LLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQV 299

Human   452 ACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVS-------SSEELKLESHTSE 509
            ||||.||.|:|...|:::|||.|.:||||.|.|.::..|..||.:       ..:::..|.:...
Mouse   300 ACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWFSYNGQCPQDIGSEDYFCV 364

Human   510 KELIMIAGGNQSILLWIKKEN-------SYVNLKRTIPTLNEGTVKRWIADVETKRWQSTKREIQ 567
            |.:  .:||:||...:...:|       ...:..:.|.|:||..:::|::....:.......||.
Mouse   365 KRI--FSGGDQSFSHYSSPQNCGPPDDFRCSDPSKQIWTVNEALIQKWLSYPSGRFPVEIANEID 427

Human   568 EIFSSPACLTGSFL------RKRRTTEMMPVYLDLNKARNIFKELTQKD--WITNMITTCLKDNL 624
            ..|||..||.||||      ..|..|....|  |:|.||.:|.:|.|.|  .|:..:...|:.||
Mouse   428 GTFSSSGCLNGSFLAISNDDHYRTGTRFSGV--DMNAARLLFHKLIQPDHPQISQQVAASLEKNL 490

Human   625 LKRLPFHSPPQEALEIFFLLPECPMMHISNNWESLVVPFAKVVCKMSDQSSLVLEEYWATLQEST 689
            :.:|....|..|||..:..|||||:|...||:.::.:||...:..:......|||.:|:.|:...
Mouse   491 IPKLTSSLPDVEALRFYLTLPECPLMSDCNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPL 555

Human   690 FSKLVQMFKTAVICQLDYW------DESAEENGNVQALLEMLKKLHRSK---------------- 732
            |.|:|::||..|:..|..:      .|....|..:...|::|:.|||..
Mouse   556 FLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKTGQLIQYDKFYIHE 620

Human   733 ---------------KHKAY-----------------------------------------LRSA 741
                           :.:||                                         ::.|
Mouse   621 VQELIDIRNDYINWVQQQAYGVDVSHGVTELADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMA 685

Human   742 AIEEERESEFAL--------RPTFDLTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDL 798
            ..:..|::..:|        .|...|.|||.:::.|.:..|.:.:|.|.:|.|.|.|.||...|.
Mouse   686 IDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDA 750

Human   799 GGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLSLFNCNVANLP 863
            |||:||||..:..|::.|:||||.|.|.:..:||..|...:...:...||:|||:::|..:.:|.
Mouse   751 GGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICGLAIYNFTIVDLH 815

Human   864 FPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDR----NDTNLI 924
            |||||:||||.:.|||:|||||.|.:|:::|.|||...|:.||.|.::|.:..:.    ....|:
Mouse   816 FPLALYKKLLKRKPSLDDLKELMPAVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELV 880

Human   925 PNGSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNT 989
            .||:...||:.|::::|..|::||||.||.::::.|..||:|:|...::.||.|.||:.:::|||
Mouse   881 LNGADTAVNRQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNT 945

Human   990 DYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMKITFC 1054
            :||||..|||..|:..|.:.||||.:||:.||:|.||:||:||:||||:||:.:..:.::|:...
Mouse   946 NYDWKELEKNTEYKGEYWADHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQ 1010

Human  1055 CPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1099
            .........|: :.|||::|.||||:..||:...|.:||::|.||
Mouse  1011 STGGGESYLPV-SHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGF 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC5	XP_011530324.2	None
Herc4	NP_084390.1	RCC1 1	1..51		2/10 (20%)
		RCC1	3..49	CDD:278826	2/8 (25%)
		RCC1 2	52..101		13/48 (27%)
		RCC1	52..99	CDD:278826	12/46 (26%)
		RCC1 3	102..154		14/51 (27%)
		RCC1	102..152	CDD:278826	12/49 (24%)
		RCC1 4	156..207		24/50 (48%)
		RCC1	157..205	CDD:278826	23/47 (49%)
		RCC1 5	208..259		21/50 (42%)
		RCC1	208..257	CDD:278826	20/48 (42%)
		RCC1	260..308	CDD:278826	30/47 (64%)
		RCC1 6	261..311		31/49 (63%)
		RCC1 7	313..366		15/52 (29%)
		RCC1	313..>343	CDD:278826	13/29 (45%)
		HECTc	709..1055	CDD:238033	143/347 (41%)
		HECTc	735..1054	CDD:214523	133/319 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57432
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0001110
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103327
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X678
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730