DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC5 and herc5.4

DIOPT Version :9

Sequence 1:	XP_011530324.2	Gene:	HERC5 / 51191	HGNCID:	24368	Length:	1100	Species:	Homo sapiens
Sequence 2:	XP_005160166.1	Gene:	herc5.4 / 100148091	ZFINID:	ZDB-GENE-090311-7	Length:	995	Species:	Danio rerio

Alignment Length:	941	Identity:	318/941 - (33%)
Similarity:	492/941 - (52%)	Gaps:	107/941 - (11%)

- Green bases have known domain annotations that are detailed below.

Human   246 KNMKIHSVDQGAEHMLILSSDGKPFEYDNYSMKHLRFESILQEKKIIQITCGDYHSLALSKGGEL 310
            :|.:|.|:..|....::|:.|||....|..::  .|....|:.:::|||.|||.||:|||..|:|
Zfish    74 QNERIRSIVCGEAGAVLLADDGKVLIMDQSTV--CRPLKSLENRQVIQIACGDQHSMALSNDGQL 136

Human   311 FAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLG 375
            |.||:|.|||||:.::...|.:||.::.|..:|:||||||..||..||:||.::.||.|..||||
Zfish   137 FVWGENTHGQLGLRKEQAGTQSPQHLQSLCEIPVAQISAGGNHSFVLSLSGVVFGWGSNSAGQLG 201

Human   376 LGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLV 440
            ||.|:.:..|::::.|..:|...::|||.|:|.|::.|.:||||:|..|||||||.::|..|.|:
Zfish   202 LGDTKDRFVPTIVKSLCGKKTVSISCGGEHTATLSKGGTVFTFGSGGFGQLGHNSLKDEHHPRLI 266

Human   441 AELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLES 505
            |||.|.:|:|:.|||.|||.:......::|||.|..||||||....|.:||||.:.:    :...
Zfish   267 AELWGSKVSQVTCGRHHTLVFEESSKLIYSFGCGMQGQLGNGEQVKQSVPLPVLLPT----ECTE 327

Human   506 HTSEKELIMIAGGNQSILLWIKKENSYVNLKRT-----IPTLNEGTVKRWIADVETKRWQSTKRE 565
            .|.||   :|.|.:.|..|:.|...:.....::     |.|||:..:.||::  |:..|.:.|.|
Zfish   328 FTMEK---LITGEHHSFALFFKNPGNESEKPKSGSNGGILTLNDRMIDRWVS--ESDPWPTVKNE 387

Human   566 IQEIFSSPACLTGSFLRKRR----TTEMMPVYLDLNKARNIFKELTQKDWITNMITTCLKDNLLK 626
            |..:|||.|.|.||||:..|    .|.:....||.:..:..|.:|.....:.:.:...::..||.
Zfish   388 INTVFSSAASLNGSFLKTSRDEHYQTSVEHCGLDFDLVKTSFAKLFASKSLISEVVKVVQQTLLP 452

Human   627 RLPFHSPPQEALEIFFLLPECPMMHISNNWESLVVPFAKVVCKMSDQSSLVLEEYWATLQESTFS 691
            .|..:....|||.::.||||. :..:......|:...|..:.:::..:..|||.||:.|.:..|.
Zfish   453 SLNPNPTGVEALRLYLLLPEL-INGLKKQRTKLIEALASKILELNSAARKVLEMYWSRLPDDWFE 516

Human   692 KLVQMF---KTAVICQL-DYWD-ESAEENGNVQALLEMLKKLHRS-------------------- 731
            :|:::|   .|.:|.|: |..| :|.....|:..:|:|..::..|
Zfish   517 RLIKLFHKESTDLIDQICDETDHQSTRHLKNILEILQMAYQISCSTDITHHDFIIHKINDLLDLL 581

Human   732 ------------------------KKHKAYLRSAAI--------------------EEE---RES 749
                                    |..:.|.|:..|                    :||   ...
Zfish   582 QTITADLLRMELYMQINEDFHDMVKLEEYYFRTVKILVKFPFASDFITKQRMFNLLQEECFRNVP 646

Human   750 EFALRPTFD--LTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAE 812
            ..|:..:|.  |.:.|..::.|.|..|.| ........|.|:|.||.|.|:.|:..|||..:...
Zfish   647 NLAMGNSFSNLLHINRESVLTDTLQYLRQ-NTHSFMHPLQVAFIGEDGIDMRGLSAEFFSLISKS 710

Human   813 MIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLSLFNCNVANLPFPLALFKKLLDQMP 877
            .|:.:..:....| :|.:||........|.:::.||:||::|:|.:..|:.||||||||||.|.|
Zfish   711 FIEWDKKILEVHE-SSLVWFNPHHTRGNKNFYYLGVICGMALYNRHHINIDFPLALFKKLLQQKP 774

Human   878 SLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSSITVNQTNKRDYVS 942
            ||:||:||||...::|:.||:::.:....:.::.|..    ....|:||||.|.||:.|::.||.
Zfish   775 SLDDLEELSPVEARSLKNLLEEDEEEVVNLQHLDFTC----KGQELVPNGSQIQVNKVNRQKYVD 835

Human   943 KYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYN 1007
            .|::..||.|||..:|:|.|||.|.|..|...:||||||::::.|:..|:||..:::|.|| |.:
Zfish   836 LYVDLEFNKSVKTQFEQFTRGFSKGCPLDAWTMFHPEELQELLHGSPQYNWKELQQSASYE-GCS 899

Human  1008 SSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNN--MKITFC-CPESWNERDPIRALT 1069
            :|...|..||..|.:|:.|.|||||:||.||:|:....|:.  :||:.. ||:. ::..| .|.|
Zfish   900 ASDELIKNFWTVFFELSEENKKKFLMFLYGTERVPAGGLSKRALKISQTDCPDP-DDHLP-EAQT 962

Human  1070 CFSVLFLPKYSTMETVEEALQEAINNNRGFG 1100
            ||..|.|||||.:.|:.:.|..|||:...||
Zfish   963 CFERLVLPKYSDINTLHDKLIHAINSCAVFG 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC5	XP_011530324.2	None
herc5.4	XP_005160166.1	RCC1_2	117..146	CDD:290274	18/28 (64%)
		RCC1	133..183	CDD:278826	24/49 (49%)
		RCC1	186..235	CDD:278826	20/48 (42%)
		RCC1	239..286	CDD:278826	27/46 (59%)
		RCC1	294..343	CDD:278826	21/55 (38%)
		HECTc	658..993	CDD:294058	131/343 (38%)
		HECTc	682..992	CDD:214523	125/317 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57432
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0001110
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X678
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	9	9.290