Protein Alignment CRBN and crbn

DIOPT Version :10

• Sequence 1: NP_057386.2
• Gene: CRBN / 51185
• HGNCID: 30185
• Length: 442
• Species: Homo sapiens
• Sequence 2: NP_001008192.1
• Gene: crbn / 493554
• XenbaseID: XB-GENE-973907
• Length: 447
• Species: Xenopus tropicalis
• Alignment Length: 443
• Identity: 325/443 - (73%)
• Similarity: 380/443 - (85%)
• Gaps: 4/443 - (0%)

Human     4 EGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFH 68
            ||::....:||||.|.::.:|||||||||:||..:.:::.||||||||||||||.|||.||||||
 Frog     5 EGEEDPGINNMGNLLQVISSESEEEDEMELEDAKTADSESPNIINFDTSLPTSHAYLGVDMEEFH 69

Human    69 GRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREA 133
            |||||||||||.|||||.|.::|||||||||.|..||||||||.|||:||||||||||:..:|||
 Frog    70 GRTLHDDDSCQQIPVLPHVQVMLIPGQTLPLHLSRPQEVSMVRGLIQRDRTFAVLAYSDGLQREA 134

Human   134 QFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQ 198
            .|||||||||||||.:||||.|||||||||||:|||.|||:||||.|:||||||.|||..|:::|
 Frog   135 HFGTTAEIYAYREEHEFGIETVKVKAIGRQRFQVLETRTQADGIQVARVQILPERVLPCPMTSLQ 199

Human   199 LESLNKCQIFP-SKPVS-REDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQL 261
            |:|.::..:|| :|||| |..|...:|..||::|||..|:|||||.|||:||||::||:|:|.||
 Frog   200 LDSQSRHLLFPTNKPVSGRSPQSKCQWLHKYRRRKFLGASLTSWPSWLYALYDADSLMERVKLQL 264

Human   262 REWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQC 326
            .||||||:|||||:|||||||||||||||||.||||||:||:||||||||||||:||||||||.|
 Frog   265 HEWDENLRDDSLPANPIDFSYRVAACLPIDDALRIQLLQIGNAIQRLRCELDIMSKCTSLCCKHC 329

Human   327 QETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQC 391
            .:|||||||||||||||||||||||||||||||||||||.||:|:||||||:|||||:|||:|||
 Frog   330 PDTEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKAFNLSLVGRPSTENSWFPGFAWTIAQC 394

Human   392 KICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPD-TEDEISPD-KVILCL 442
            ::|.||:||||||.:||:|||||||||||||.|.||: .|.|:..| ..||||
 Frog   395 RVCGSHMGWKFTAVRKDLSPQKFWGLTRSALQPRIPEPDEGEMGHDHSPILCL 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CRBN	NP_057386.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		18/40 (45%)
		LON_substr_bdg	80..317	CDD:426647	173/238 (73%)
		CRBN_C_like	321..422	CDD:276940	84/100 (84%)
crbn	NP_001008192.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47		19/41 (46%)
		LON_substr_bdg	82..320	CDD:426647	173/237 (73%)
		CRBN_C_like	324..425	CDD:276940	84/100 (84%)