Protein Alignment CRBN and crbn

DIOPT Version :10

• Sequence 1: NP_057386.2
• Gene: CRBN / 51185
• HGNCID: 30185
• Length: 442
• Species: Homo sapiens
• Sequence 2: NP_001003996.1
• Gene: crbn / 445491
• ZFINID: ZDB-GENE-040822-43
• Length: 431
• Species: Danio rerio
• Alignment Length: 440
• Identity: 307/440 - (69%)
• Similarity: 367/440 - (83%)
• Gaps: 20/440 - (4%)

Human    14 MGNHLPLLPA-ESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDS 77
            |||.|.|||. |.||||:||.||:|.::.:||:||||||||||||.|||:||||||||||||:||
Zfish     1 MGNQLQLLPENEEEEEDDMETEDRDGEDVEKPSIINFDTSLPTSHAYLGSDMEEFHGRTLHDEDS 65

Human    78 CQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYS---NVQEREAQFGTTA 139
            .|.:||||.|.:|||||||||||||.||||||.|||:.:||||||||:|   :..|.:|:|||||
Zfish    66 VQNLPVLPHVALILIPGQTLPLQLFRPQEVSMFRNLVSQDRTFAVLAHSPDPSGTETKAEFGTTA 130

Human   140 EIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNK 204
            ||||:||||::|||.||:||:|||||:|.::|||:|||:|||||||||.:||..:.|:|...
Zfish   131 EIYAFREEQEYGIETVKIKAVGRQRFRVHDIRTQADGIRQAKVQILPERILPDPLCALQFLP--- 192

Human   205 CQIFPSKPVSREDQ-------CSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLR 262
             ::....|.::..|       ||    |.|:::|.|||::||||.|:|||||::|||.|:||||.
Zfish   193 -RLHTHSPQTKHTQTTPPQKRCS----QNYRQKKLHCASMTSWPPWVYSLYDSKTLMSRVKKQLH 252

Human   263 EWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQ 327
            ||||||||:|||:||.||||||||||||||.||:|||||||||||||||||||::||||||||||
Zfish   253 EWDENLKDESLPTNPTDFSYRVAACLPIDDALRLQLLKIGSAIQRLRCELDIMDRCTSLCCKQCQ 317

Human   328 ETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCK 392
            :||||:|||||||||.||||||||||||||||||||||.||||||||||.||||||||||:|||:
Zfish   318 DTEITSKNEIFSLSLYGPMAAYVNPHGYVHETLTVYKASNLNLIGRPSTLHSWFPGYAWTIAQCR 382

Human   393 ICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 442
            .|:||:||||:|.|||:||.:||||||||||||||..|:.:...: :|||
Zfish   383 TCSSHMGWKFSAVKKDLSPPRFWGLTRSALLPTIPQGEEGVEGSR-LLCL 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CRBN	NP_057386.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		18/31 (58%)
		LON_substr_bdg	80..317	CDD:426647	159/246 (65%)
		CRBN_C_like	321..422	CDD:276940	85/100 (85%)
crbn	NP_001003996.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		20/34 (59%)
		LON_substr_bdg	68..307	CDD:426647	159/246 (65%)
		CRBN_C_like	311..412	CDD:276940	85/100 (85%)