Protein Alignment CRBN and M18.6

DIOPT Version :10

• Sequence 1: NP_057386.2
• Gene: CRBN / 51185
• HGNCID: 30185
• Length: 442
• Species: Homo sapiens
• Sequence 2: NP_502300.2
• Gene: M18.6 / 187461
• WormBaseID: WBGene00010891
• Length: 414
• Species: Caenorhabditis elegans
• Alignment Length: 427
• Identity: 99/427 - (23%)
• Similarity: 162/427 - (37%)
• Gaps: 91/427 - (21%)

Human    24 ESEEEDEMEVEDQDSKEAKKPNI---INFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLP 85
            |||.||..:.||.:.:..:..|:   ..||.:|..:.     :.|.:.......|......|:.
 Worm     9 ESESEDFYDAEDAEPQAMEGLNVDVTHRFDYALQDNE-----NRENYENEARLTDYGTNWFPIC- 67

Human    86 QVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRT--FAVLAYSNVQE-----------REAQFGT 137
            .|..:..|||.||:: ||..|..:...|:...|.  |.||...::.|           |..|..:
 Worm    68 GVSAVCFPGQQLPMK-FHDDEREIYERLVSSARANGFVVLFPLDIPECTSLPYIATLSRVVQANS 131

Human   138 TAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMS------A 196
            .|               :.::.:|..|.|||:...   |..:|:||:||:..|||.:.      |
 Worm   132 NA---------------LSMELMGVYRCKVLKYNL---GRGEAEVQLLPDVELPSLLPSFIPKYA 178

Human   197 VQLESLNKCQI------FPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMD 255
            :.|.:..|..|      :|...:....:.:..          .|..|.|      .:...:|:
 Worm   179 IHLPAHEKRSIATRINGYPFNAIRDVTESAVN----------ECVGLLS------GMLGDDTV-- 225

Human   256 RIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTS 320
                      ...||..|..    |||..|..:..:.:....|||..||..|:...|    |...
 Worm   226 ----------RQAKDRGLTY----FSYFAAKHIFSNRLTEYSLLKEDSANGRIVAAL----KYFK 272

Human   321 LCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYA 385
            :...:|....|........:.|......:||.||:||:...:.:..|.:....||.|.:|||.||
 Worm   273 VFVGRCSRCRIPIFRNEHIMRLPDQTMTHVNAHGFVHKITLLSEIRNYDRATPPSYEFTWFPEYA 337

Human   386 WTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSAL 422
            |.:.||..|..|:||::.:..::  |::|:|:.|..:
 Worm   338 WIIIQCSRCHEHLGWEYISMTRE--PRRFFGIQREGI 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CRBN	NP_057386.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		7/20 (35%)
		LON_substr_bdg	80..317	CDD:426647	56/261 (21%)
		CRBN_C_like	321..422	CDD:276940	29/100 (29%)
M18.6	NP_502300.2	LON	60..138	CDD:197740	19/94 (20%)
		CRBN_C_like	277..372	CDD:276940	29/96 (30%)