Protein Alignment DCXR and Dhrs4

DIOPT Version :10

• Sequence 1: NP_057370.1
• Gene: DCXR / 51181
• HGNCID: 18985
• Length: 244
• Species: Homo sapiens
• Sequence 2: NP_647946.1
• Gene: Dhrs4 / 38598
• FlyBaseID: FBgn0035588
• Length: 317
• Species: Drosophila melanogaster
• Alignment Length: 255
• Identity: 76/255 - (29%)
• Similarity: 123/255 - (48%)
• Gaps: 24/255 - (9%)

Human     5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRE------------CPGIEPV 57
            |||:..:||.:..|||....:.|...||.||..||.|.::||.:.|            |...||.
  Fly    69 LAGKVAVVTASTDGIGFAIAKRLAEDGAAVVISSRKQKNVDSALAELRKLNLNVHGLKCHVSEPE 133

Human    58 CVDLGDWEATERALGSVGPVDLLVNNAAV-ALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR- 120
                ...:..|..:...|.:::||:|||. ..:...||..::.:|:.|:||:::    |.::|:
  Fly   134 ----DRKQLFEETISKFGKLNILVSNAATNPAVGGVLECDEKVWDKIFDVNVKS----SYLLAKE 190

Human   121 --GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVM 183
              .|:.:....:||.|||.....|......|..:|.||..|||..|.:|.|..||||.:.|.|:.
  Fly   191 ALPLLRQQKNSSIVFVSSIAGYDAFELLGAYSVSKTALIGLTKAAAKDLAPEGIRVNCLAPGVIR 255

Human   184 TSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGFWA 243
            |...:|.:.:....:..|::||:|:....|.:...:.||:|:.:|..||.::...||..|
  Fly   256 TKFSKALYENESANEAALSKIPMGRLGTSEEMAGVVSFLVSEDAGYITGESIVAGGGMTA 315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DCXR	NP_057370.1	XR_like_SDR_c	1..244	CDD:187609	76/255 (30%)
Dhrs4	NP_647946.1	Rossmann-fold NAD(P)(+)-binding proteins	67..317	CDD:473865	76/255 (30%)