DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HAO2 and CG18003

DIOPT Version :9

Sequence 1:	XP_016856910.1	Gene:	HAO2 / 51179	HGNCID:	4810	Length:	420	Species:	Homo sapiens
Sequence 2:	NP_001027401.1	Gene:	CG18003 / 3771779	FlyBaseID:	FBgn0061356	Length:	366	Species:	Drosophila melanogaster

Alignment Length:	353	Identity:	159/353 - (45%)
Similarity:	219/353 - (62%)	Gaps:	18/353 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    14 MSLVCLTDFQAHAREQLSKSTRDFIEGGADDSITRDDNIAAFKRIRLRPRYLRDVSEVDTRTTIQ 78
            |:|||:.||:..|..||.|:..|:...||.:..|...|..||:|:|||||.|||||.:|..|.|.
  Fly     1 MALVCVEDFEKKAVGQLEKNALDYYRSGAGEQFTLGLNREAFRRLRLRPRCLRDVSRLDISTKIF 65

Human    79 GEEISAPICIAPTGFHCLVWPDGEMSTARAAQAAGICYITSTFASCSLEDIVIAAPEGLRWFQLY 143
            ||::..|:.||||....:..||||:..||||..||..:|.||.::.||||:...||:.::|||||
  Fly    66 GEQMQWPLGIAPTAMQKMAHPDGEVGNARAAGKAGSIFILSTLSTTSLEDLAAGAPDTIKWFQLY 130

Human   144 VHPDLQLNKQLIQRVESLGFKALVITLDTPVCGNRRHDIRN--QLRRNLTLTDLQSPKK---GNA 203
            ::.|..:.::|::|.|...|||||:|:|.|:.|:||.|:||  .|..:|:|.:.|..|.   |||
  Fly   131 IYKDRTITEKLVRRAEKANFKALVLTIDAPIFGHRRADVRNNFSLPSHLSLANFQGVKATGVGNA 195

Human   204 ------IPYFQMTPISTSLCWNDLSWFQSITRLPIILKGILTKEDAELAVKHNVQGIIVSNHGGR 262
                  |..:..:....::.|.|::|.:.||.|||::||:||.|||.||.:....|:||||||.|
  Fly   196 AMGASGINEYVSSQFDPTITWKDIAWLKGITHLPIVVKGVLTAEDAVLAQEFGCAGLIVSNHGAR 260

Human   263 QLDEVLASIDALTEVVAAVKGKIEVYLDGGVRTGNDVLKALALGAKCIFLGRPILWGLAC---KA 324
            |:|.|.|||:||.|:|.||...:.|.||||:..|||:.||||||||.:|:|||.:||||.   |.
  Fly   261 QIDTVPASIEALPEIVKAVGDNLVVMLDGGIMQGNDIFKALALGAKTVFVGRPAVWGLAYNGQKG 325

Human   325 AGRSL----RSIETWSSFPGCKKKGPIT 348
            ....|    :..||..:..||:..|.||
  Fly   326 VEEMLSVLRKDFETTMALIGCQNLGDIT 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HAO2	XP_016856910.1	alpha_hydroxyacid_oxid_FMN	21..326	CDD:239203	147/318 (46%)
CG18003	NP_001027401.1	alpha_hydroxyacid_oxid_FMN	7..353	CDD:239203	153/345 (44%)
CG18003	NP_001027401.1	FMN_dh	17..359	CDD:279418	151/337 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140699
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54906
OrthoDB	1	1.010	-	-		D500918at33208
OrthoFinder	1	1.000	-	-		FOG0001123
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100930
Panther	1	1.100	-	-	O	PTHR10578
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1926
SonicParanoid	1	1.000	-	-		X693
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.890