Protein Alignment HSD17B14 and CG18814

DIOPT Version :10

• Sequence 1: NP_057330.2
• Gene: HSD17B14 / 51171
• HGNCID: 23238
• Length: 270
• Species: Homo sapiens
• Sequence 2: NP_652673.2
• Gene: CG18814 / 59175
• FlyBaseID: FBgn0042137
• Length: 267
• Species: Drosophila melanogaster
• Alignment Length: 286
• Identity: 80/286 - (27%)
• Similarity: 115/286 - (40%)
• Gaps: 62/286 - (21%)

Human     9 GKVVVVTGGGRGIGAGIVRAFVNSGAR-VVICD---KDESGGRALEQELPGAVFI-LCDVTQEDD 68
            ||.||..||..|||...|:..:....: :.|.|   .|:......:|.....:|. ..|:||:.|
  Fly     5 GKNVVYLGGFGGIGKKCVQELLKKQIKGLAIFDLIVDDDLLAEWKKQHPDTEIFYQKMDITQKSD 69

Human    69 VKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLALPYLRKSQ 133
            :......|..:.|..|.|||.:| ....:|.|.|        :::||:|....|..||.|:.||:
  Fly    70 IDAAYKATAEKLGHFDVVVNGSG-LLDDRRIELT--------IQINLVGVINSTLTALEYMDKSK 125

Human   134 GN----VINISSLVGAIGQAQAVP----YVATKGAVTAMTKALALDESPY-----GVRVNCISPG 185
            |.    ::||||:.|    .|..|    |..:|..||..|:|:|   ||.     ||....|.||
  Fly   126 GGRGGLIVNISSVAG----LQPTPLMAIYSTSKTGVTTFTRAMA---SPIHYAHSGVGFITICPG 183

Human   186 NIWTPLWEELAALMPDPRAT--IREGMLAQPLGRM-GQPAEVGAAAVFLASEANFCTGIELLVTG 247
            ...|.:.:::     |.:.|  ..|..:.....:: ||.|||.|        .|....||....|
  Fly   184 YTNTGILKDI-----DKKTTFPFYETRMRTVFSKVKGQTAEVCA--------RNIVNAIETAKNG 235

Human   248 GA---ELGYGCKASRSTPVDAPDIPS 270
            ..   |||         .:...|||:
  Fly   236 AVLMLELG---------EIHELDIPN 252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSD17B14	NP_057330.2	RDH_SDR_c	1..256	CDD:187638	77/270 (29%)
CG18814	NP_652673.2	Rossmann-fold NAD(P)(+)-binding proteins	6..248	CDD:473865	76/279 (27%)