Protein Alignment HSD17B14 and CG12171

DIOPT Version :10

• Sequence 1: NP_057330.2
• Gene: HSD17B14 / 51171
• HGNCID: 23238
• Length: 270
• Species: Homo sapiens
• Sequence 2: NP_649563.1
• Gene: CG12171 / 40690
• FlyBaseID: FBgn0037354
• Length: 257
• Species: Drosophila melanogaster
• Alignment Length: 251
• Identity: 92/251 - (36%)
• Similarity: 134/251 - (53%)
• Gaps: 13/251 - (5%)

Human     7 YAGKVVVVTGGGRGIGAGIVRAFVNSGARVVI----CDK-DESGGRALEQELPGAVFILCDVTQE 66
            :..||::|||...|||||........|..:.|    .|| :|:..:.:......|:.:..|:..|
  Fly     4 FKDKVIIVTGASSGIGAGTSVLLAKLGGLLTIVGRNLDKLNETAEQIVAAGGAPALQVAADINSE 68

Human    67 DDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLALPYLRK 131
            .||:.:||.|:.:.||:|.:|||||...... .|.||.:.|.:::..|:...|.||.|..|.|.|
  Fly    69 SDVQGIVSATLAKHGRIDVLVNNAGILELGS-IENTSLEQFDRVMNTNVRSLYQLTHLVTPELIK 132

Human   132 SQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELA 196
            ::||::|:||:.|.......:.|..:|.||...|:.:||:.:|.|||||.::||.|.|.| :...
  Fly   133 TKGNIVNVSSVNGIRSFPGVLAYNVSKAAVDQFTRCVALELAPKGVRVNSVNPGVIITEL-QRRG 196

Human   197 ALMPDPRATIR---EGMLAQPLGRMGQPAEVGAAAVFLAS-EANFCTGIELLVTGG 248
            .|  |..|.::   ...:...|||.|:..||.||..|||| ||:|.|||.|.|.||
  Fly   197 GL--DQEAYVKFLEHAKVTHALGRPGEVKEVAAAIAFLASDEASFSTGISLPVDGG 250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSD17B14	NP_057330.2	RDH_SDR_c	1..256	CDD:187638	92/251 (37%)
CG12171	NP_649563.1	Rossmann-fold NAD(P)(+)-binding proteins	4..254	CDD:473865	92/251 (37%)