Protein Alignment HSD17B14 and Dhrs4

DIOPT Version :10

• Sequence 1: NP_057330.2
• Gene: HSD17B14 / 51171
• HGNCID: 23238
• Length: 270
• Species: Homo sapiens
• Sequence 2: NP_647946.1
• Gene: Dhrs4 / 38598
• FlyBaseID: FBgn0035588
• Length: 317
• Species: Drosophila melanogaster
• Alignment Length: 260
• Identity: 88/260 - (33%)
• Similarity: 133/260 - (51%)
• Gaps: 27/260 - (10%)

Human     3 TGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGG-------RALEQELPGAVFIL 60
            |..|.||||.|||....|||..|.:.....||.|||..:.:...       |.|...:.|   :.
  Fly    65 TMKRLAGKVAVVTASTDGIGFAIAKRLAEDGAAVVISSRKQKNVDSALAELRKLNLNVHG---LK 126

Human    61 CDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLA 125
            |.|::.:|.|.|..|||.:||:|:.:|:||..:|......|...:.:.::.::|:..:|.|.|.|
  Fly   127 CHVSEPEDRKQLFEETISKFGKLNILVSNAATNPAVGGVLECDEKVWDKIFDVNVKSSYLLAKEA 191

Human   126 LPYLRKSQ-GNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWT 189
            ||.||:.: .:::.:||:.|.........|..:|.|:..:|||.|.|.:|.|:||||::||.|.|
  Fly   192 LPLLRQQKNSSIVFVSSIAGYDAFELLGAYSVSKTALIGLTKAAAKDLAPEGIRVNCLAPGVIRT 256

Human   190 ----PLWEELAALMPDPRATIREGMLAQ-PLGRMGQPAEVGAAAVFLASE-ANFCTGIELLVTGG 248
                .|:|..:|         .|..|:: |:||:|...|:.....||.|| |.:.|| |.:|.||
  Fly   257 KFSKALYENESA---------NEAALSKIPMGRLGTSEEMAGVVSFLVSEDAGYITG-ESIVAGG 311

Human   249  248
              Fly   312  311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSD17B14	NP_057330.2	RDH_SDR_c	1..256	CDD:187638	88/260 (34%)
Dhrs4	NP_647946.1	Rossmann-fold NAD(P)(+)-binding proteins	67..317	CDD:473865	87/258 (34%)