Protein Alignment HSD17B14 and CG31548

DIOPT Version :10

• Sequence 1: NP_057330.2
• Gene: HSD17B14 / 51171
• HGNCID: 23238
• Length: 270
• Species: Homo sapiens
• Sequence 2: NP_730974.1
• Gene: CG31548 / 318794
• FlyBaseID: FBgn0051548
• Length: 256
• Species: Drosophila melanogaster
• Alignment Length: 256
• Identity: 89/256 - (34%)
• Similarity: 130/256 - (50%)
• Gaps: 23/256 - (8%)

Human     7 YAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALE-------------QELPGAVF 58
            :|||||::||...||||.....|...||.:.:      .||.:|             |..|  ..
  Fly     3 FAGKVVLITGASSGIGAATAIKFAKYGACLAL------NGRNVENLKKVAAECSKVSQSQP--AL 59

Human    59 ILCDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTK 123
            ::.|:.:|.|.:.:.|||::::|:||.:||||| .......|.||.:.:.:::..||...|.||.
  Fly    60 VVGDIAKEADTQRIWSETLQQYGKLDVLVNNAG-IIETGTIETTSLEQYDRVMNTNLRAIYHLTM 123

Human   124 LALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIW 188
            ||.|.|.|::||::|:||:.|.......:.|..:|..|...|:.:||:.:..||||||::||...
  Fly   124 LATPELVKTKGNIVNVSSVNGIRSFPGVLAYNISKMGVDQFTRCVALELAAKGVRVNCVNPGVTV 188

Human   189 TPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLAS-EANFCTGIELLVTGG 248
            |.|...........:..:........|||.|...||.||..|||| ||:|.||:.|.|.||
  Fly   189 TNLHARGGMDAETYKKFLEHSKTTHALGRPGDVKEVAAAIAFLASDEASFSTGVSLPVDGG 249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSD17B14	NP_057330.2	RDH_SDR_c	1..256	CDD:187638	89/256 (35%)
CG31548	NP_730974.1	Rossmann-fold NAD(P)(+)-binding proteins	3..253	CDD:473865	89/256 (35%)