Protein Alignment HSD17B14 and CG3699

DIOPT Version :10

• Sequence 1: NP_057330.2
• Gene: HSD17B14 / 51171
• HGNCID: 23238
• Length: 270
• Species: Homo sapiens
• Sequence 2: NP_569875.2
• Gene: CG3699 / 31046
• FlyBaseID: FBgn0040349
• Length: 251
• Species: Drosophila melanogaster
• Alignment Length: 253
• Identity: 86/253 - (33%)
• Similarity: 135/253 - (53%)
• Gaps: 24/253 - (9%)

Human     8 AGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPG--AVFILCDVTQEDDVK 70
            :.|||:|||...||||.|.:.....||.:.:..::.:...|.::.|.|  |..::.|||::.|
  Fly     4 SNKVVIVTGASSGIGAAIAQVLAREGATLALVGRNVANLEATKKSLKGTQAEIVVADVTKDAD-- 66

Human    71 TLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQG---------FRQLLELNLLGTYTLTKLAL 126
            .:|.:|:.:|||:|.:|||||          ...:|         |..:|..||.|...|||..|
  Fly    67 AIVQQTLAKFGRIDVLVNNAG----------ILGKGGLIDLDIEEFDAVLNTNLRGVILLTKAVL 121

Human   127 PYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPL 191
            |:|.|::|.|:|:||..|....|.|:.|..:|.|:...||.:||:.:|.|||||.::||.:.|.:
  Fly   122 PHLLKTKGAVVNVSSCAGIRPFAGALSYGVSKAALDQFTKIVALEMAPQGVRVNSVNPGFVVTNI 186

Human   192 WEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLA-SEANFCTGIELLVTGG 248
            ...:..:..:....::..:.:.|:||:|...||..|..||| |:|:|.||....:.||
  Fly   187 HRNIGIVDEEYNGMLQRAINSHPMGRVGDVTEVAEAVAFLASSKASFTTGALFPIDGG 244

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSD17B14	NP_057330.2	RDH_SDR_c	1..256	CDD:187638	86/253 (34%)
CG3699	NP_569875.2	Rossmann-fold NAD(P)(+)-binding proteins	3..248	CDD:473865	86/253 (34%)