Protein Alignment HSD17B11 and naz

DIOPT Version :10

• Sequence 1: NP_057329.3
• Gene: HSD17B11 / 51170
• HGNCID: 22960
• Length: 300
• Species: Homo sapiens
• Sequence 2: NP_732328.1
• Gene: naz / 42204
• FlyBaseID: FBgn0286852
• Length: 406
• Species: Drosophila melanogaster
• Alignment Length: 219
• Identity: 58/219 - (26%)
• Similarity: 89/219 - (40%)
• Gaps: 38/219 - (17%)

Human    37 EIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCK-GLGAK-------------- 86
            :||::||...|||...|...|....:::|...|....:..||..| .||.:
  Fly    50 QIVVVTGGNSGIGFEIAQALAGRGGRIILACRNLEAGKRAAAIIKRELGCRTPLNSLDEDDNPED 114

Human    87 ---VHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAH 148
               |....:|..:...::..|.::.||...:.:||||||||:.:....|:| ..|:..:||.||.
  Fly   115 RYFVEARYLDLCSLRSVHHFAGQLMAEFERIDVLVNNAGVVFANTQMPTED-GFERHSQVNYLAP 178

Human   149 FWTTKAFLPAMTKNNHGHIVTVASAA--------------GHVSVPFLL--AYCSSKFAAVGFHK 197
            |..|...||.:.::..|.|:.|::.|              |..||.|..  |:..||...:...:
  Fly   179 FLLTHLLLPHLQRSEQGRILFVSAHAHQGAKIDFDDPLNVGTWSVKFHAREAFAHSKLCVLLATR 243

Human   198 TLTDELAALQITGVKTTCLCPNFV 221
            .:..||..   |.|...|..|..|
  Fly   244 WMARELKG---TSVTVNCCTPGLV 264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSD17B11	NP_057329.3	17beta-HSDXI-like_SDR_c	38..277	CDD:187598	58/218 (27%)
naz	NP_732328.1	retinol-DH_like_SDR_c_like	50..342	CDD:212492	58/219 (26%)