Protein Alignment HSD17B11 and spidey

DIOPT Version :10

• Sequence 1: NP_057329.3
• Gene: HSD17B11 / 51170
• HGNCID: 22960
• Length: 300
• Species: Homo sapiens
• Sequence 2: NP_572420.1
• Gene: spidey / 31703
• FlyBaseID: FBgn0029975
• Length: 321
• Species: Drosophila melanogaster
• Alignment Length: 282
• Identity: 80/282 - (28%)
• Similarity: 125/282 - (44%)
• Gaps: 32/282 - (11%)

Human    33 SVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAK----VHTFVVD 93
            |..||..::||:..|||:..|.|.|:...||||  |:: .||:.....|.:|.|    |....||
  Fly    49 SKMGEWAVVTGSTDGIGKAYAKELARRGLKLVL--ISR-SLEKLNVVAKEIGDKYGVEVRVIDVD 110

Human    94 CSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTS-----DLFATQDPQIEKTFEVNVLAHFWTTK 153
            .:..::||...::....: :|.:||||.|:.|..     |.:....|.:......|:.:....|.
  Fly   111 FTGGDEIYDKIREKTTGL-NVGVLVNNVGISYGHPEYFLDCYKADPPFLRNIVAANIHSVTHMTA 174

Human   154 AFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDEL-AALQITGVKTTCLC 217
            .|||.|.....|.|:.|:|.||.:..|.|..|.|:|    .|....:|:| ...:..|:....:.
  Fly   175 LFLPGMISQRRGVIINVSSTAGVIPNPLLSVYSSTK----AFVNKFSDDLQTEYKEHGILIQSVQ 235

Human   218 PNFVNTGFIKNPSTSL-GPTLEPEEVVNRLMH--GILTEQKMIFIPSSIAFLTT--LERILPERF 277
            |.||.|...|....|: .|:  ||..|...:.  ||.| |...::|.::..|..  .|.:..|:|
  Fly   236 PGFVATNMSKIRKASVFAPS--PETYVRSALSTLGIAT-QTAGYLPHALLQLVIHFTEAVFGEQF 297

Human   278 LAVLKRKISVKFDAVIGYKMKA 299
                .|.|.:|  .::|.:.:|
  Fly   298 ----ARNIVMK--NILGTRKRA 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSD17B11	NP_057329.3	17beta-HSDXI-like_SDR_c	38..277	CDD:187598	71/253 (28%)
spidey	NP_572420.1	17beta-HSD1_like_SDR_c	52..288	CDD:187614	71/246 (29%)