Protein Alignment HSD17B11 and CG3842

DIOPT Version :10

• Sequence 1: NP_057329.3
• Gene: HSD17B11 / 51170
• HGNCID: 22960
• Length: 300
• Species: Homo sapiens
• Sequence 2: NP_572316.1
• Gene: CG3842 / 31576
• FlyBaseID: FBgn0029866
• Length: 406
• Species: Drosophila melanogaster
• Alignment Length: 295
• Identity: 77/295 - (26%)
• Similarity: 116/295 - (39%)
• Gaps: 86/295 - (29%)

Human     4 LLDILLLLPLLIVCSLESFVKLFIPKRRKS--VTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLW 66
            :|.|||.:.||..|       :..|..||:  :.|::|::||...|||:.|..|.||..:::.:
  Fly    47 VLGILLFMWLLRKC-------IQGPAYRKANRIDGKVVIVTGCNTGIGKETVLELAKRGARVYM- 103

Human    67 DINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSS-------------AKKVKAEIGDVSILV 118
                      |.:..|........::|.|..:.:::.             .::.|||...:.||:
  Fly   104 ----------ACRDPGRCEAARLDIMDRSRNQQLFNRTLDLGSLQSVRNFVERFKAEESRLDILI 158

Human   119 NNAGVV-----YTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAA---G 175
            |||||:     .|:|.|       |:.|.||.|.||..|...|..:..::...||.|:|||   |
  Fly   159 NNAGVMACPRTLTADGF-------EQQFGVNHLGHFLLTNLLLDRLKHSSPSRIVVVSSAAHLFG 216

Human   176 HVS----------VPFLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTG------ 224
            .::          ..|..||..||.|.:.|...|:   ..|:.|||...|..|..|.|.
  Fly   217 RINREDLMSEKNYSKFFGAYSQSKLANILFTLKLS---TILKDTGVTVNCCHPGVVRTEINRHFS 278

Human   225 ---------------FIKNP----STSLGPTLEPE 240
                           |.|.|    .|.|...|:|:
  Fly   279 GPGWMKTALQKGSLYFFKTPKAGAQTQLRLALDPQ 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSD17B11	NP_057329.3	17beta-HSDXI-like_SDR_c	38..277	CDD:187598	66/259 (25%)
CG3842	NP_572316.1	Rossmann-fold NAD(P)(+)-binding proteins	74..347	CDD:473865	67/261 (26%)