Protein Alignment MYO15A and MYO4

DIOPT Version :9

• Sequence 1: XP_016880204.1
• Gene: MYO15A / 51168
• HGNCID: 7594
• Length: 3531
• Species: Homo sapiens
• Sequence 2: NP_009373.1
• Gene: MYO4 / 851204
• SGDID: S000000027
• Length: 1471
• Species: Saccharomyces cerevisiae
• Alignment Length: 1259
• Identity: 372/1259 - (29%)
• Similarity: 568/1259 - (45%)
• Gaps: 309/1259 - (24%)

Human  1207 IRNLPSMRFREQHGEDGVEDMTQLEDLQETTVLSNLKIRFERNLIYTYIGSILVSVNPY-QMFGI 1270
            :||.|.:        :..:|:|.|..|.|..||..:|.|:....||||.|.:|::.||: ::..:
Yeast    64 LRNPPIL--------ESTDDLTTLSYLNEPAVLHAIKKRYMNGQIYTYSGIVLIAANPFDKVDHL 120

Human  1271 YGPEQVQQYNGRALGENPPHLFAVANLAFAKMLDAKQNQCIIISGESGSGKTEATKLILRYLAAM 1335
            |..|.:|.|:.:...|..|||||:|..|:..|:..|.||.:::|||||:|||.:.|.|:||.|::
Yeast   121 YSREMIQNYSSKRKDELEPHLFAIAEEAYRFMVHEKANQTVVVSGESGAGKTVSAKYIMRYFASV 185

Human  1336 ----NQKREV-MQQV-IQILEATPLLESFGNAKTVRNDNSSRFGKFVEI-FLEGGVISGAITSQY 1393
                |::.|| |.|: .|||...|::|:||||||.||||||||||:::| |.|...|.|:....|
Yeast   186 QESNNREGEVEMSQIESQILATNPIMEAFGNAKTTRNDNSSRFGKYLQILFDENTTIRGSKIRTY 250

Human  1394 LLEKSRIVFQAKNERNYHIFYELLAGLPAQLRQAFSLQEAETYYYLNQGGNCEIAGKSDADDFRR 1458
            ||||||:|:|.:.||||||||::|.|||..::|...|...:.|:|.||||...|||..:|.:::.
Yeast   251 LLEKSRLVYQPETERNYHIFYQILEGLPEPVKQELHLSSPKDYHYTNQGGQPNIAGIDEAREYKI 315

Human  1459 LLAAMEVLGFSSEDQDSIFRILASILHLGNVYFEKYETDAQEVASVVSARE--IQAVAELLQISP 1521
            ...|:.::|.:.|.|..||:|||.:||:||:..:....||.     :|:.|  :|...|||.|.|
Yeast   316 TTDALSLVGINHETQLGIFKILAGLLHIGNIEMKMTRNDAS-----LSSEEQNLQIACELLGIDP 375

Human  1522 EGLQKAITFKVTETMREKIFTPLTVESAVDARDAIAKVLYALLFSWLITRVN-ALVSPRQDTLS- 1584
            ....|.|..|...|..|||.|.|....|:.|||::||.:|:.||.||:..:| .|..|..|...
Yeast   376 FNFAKWIVKKQIVTRSEKIVTNLNYNQALIARDSVAKFIYSTLFDWLVDNINKTLYDPELDQQDH 440

Human  1585 ----IAILDIYGFEDLSFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQIDWQEITFADNQ 1645
                |.||||||||....|||||.|||||||.||..||:.||:.|||||::|:|:|..|.|:|||
Yeast   441 VFSFIGILDIYGFEHFEKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIEFSDNQ 505

Human  1646 PCINLISLKPYGILRILDDQCCFPQATDHTFLQKCHYHHG---ANPLYSKPKMPLPEFTIKHYAG 1707
            |||:||..| .|||.:||::...|..:|.::..|.:....   :|.::|||:....:|.:.|||.
Yeast   506 PCIDLIENK-LGILSLLDEESRLPSGSDESWASKLYSAFNKPPSNEVFSKPRFGQTKFIVSHYAV 569

Human  1708 KVTYQVHKFLDKNHDQVRQDVLDLFVRSRTRVVAHLF------SSHAPQ--------AAPQRLGK 1758
            .|.|:|..|::||.|.|....||:|..:...:...:.      |..||:        ..|.||.:
Yeast   570 DVEYEVEGFIEKNRDSVSLGHLDVFKATTNPIFKQILDNRELRSDDAPEEQNTEKKIMIPARLSQ 634

Human  1759 SSSVTRLYKAHTVAAKFQQSLLDLVEKMERCNPLFMRCLKPNHKKEPGLFEPDVVMAQLRYSGVL 1823
                    |..|:.:.|::||.:|:..:...|..::||:|||.:|:|..|:..:|::|||..|||
Yeast   635 --------KKPTLGSMFKKSLGELMAIINSTNVHYIRCIKPNSEKKPWEFDNLMVLSQLRACGVL 691

Human  1824 ETVRIRKEGFPVRLPFQGFIDRYCCL--------VALKHDLPANG--DMCVSVLSRLCKVMPNMY 1878
            ||:||...|||.|..|..|:.||..|        :....|||...  :.|.|:|......... |
Yeast   692 ETIRISCAGFPSRWTFDEFVQRYFLLTDYSLWSGILYNPDLPKEAIVNFCQSILDATISDSAK-Y 755

Human  1879 RVGVSKLFLKEHLYQLLESMREHVLNLAALTLQRCLRGFFIKRRF--------------RSL--- 1926
            ::|.:|:|.|..:...||.:|.:.:|...:.:|:.:|..:.:.::              |||
Yeast   756 QIGNTKIFFKAGMLAFLEKLRTNKMNEICIIIQKKIRARYYRLQYLQTMESIKKCQSQIRSLLVR 820

Human  1927 ------------------------------------------RHKIIL--------------LQS 1935
                                                      :.|:||              :||
Yeast   821 TRVDHELKTRAAILLQTNIRALWKREYYRAAIGQIIKLQCTCKRKLILDSVNRKFMLMAAVIIQS 885

Human  1936 RARGYLARQRYQQMRRSLVKFRSLVHAYVSRRRYLKLRAEWRCQVEGALLWEQEELSKREVVAVG 2000
            ..|.|..:..|:.::||.:..:|.:...::||||:.|               |:|:.:|.:
Yeast   886 YIRSYGHKTDYRTLKRSSILVQSAMRMQLARRRYIVL---------------QKEVEERNI---- 931

Human  2001 HLEVPAELAGLLQAVAGLGLAQVPQVAPVRTPRLQAEPRVTLPLDINNYPMAKFVQCHFKEPAFG 2065
                        :|..|:||.:         ..::.:....|.|::.|             .::.
Yeast   932 ------------RASYGIGLLE---------EAIEFKNSFILNLEMLN-------------DSYT 962

Human  2066 MLTVPLRTPLTQLPAEHHAEAVSIFKLILRFMGDPHLHGARENIFGNYIVQKGLAVPELRDEI-- 2128
            .||..|:..|:.:|::...|                    .|.|...|           .|:|
Yeast   963 RLTQLLQGDLSNIPSKQRQE--------------------YETIVNGY-----------NDKISK 996

Human  2129 LAQLANQVWHNHNAHNA--ER---------GWLLLAACLSGFAPSPCFN-----KYLLKFVSD-- 2175
            |..|..::.:..|..||  ||         ..:...|.:.|..||...:     |..|.|:.:
Yeast   997 LKTLQVEIMNTLNKKNALKERKKKQSSLIQSHMQSLAAIKGNKPSRLSDEVKSMKQELAFIENVI 1061

Human  2176 -------YGRNGFQAVCQHRLMQAMGRAQQQ-----------GSGAARTLPPTQLEWTATYEKAS 2222
                   |..|      ::..::.:|.|.||           .||     .|..||
Yeast  1062 AQDFTTTYSAN------KNDKVKGLGIAGQQVKPKLVNVIRRESG-----NPDLLE--------- 1106

Human  2223 MALDVGCF-----------------NGDQFSCPVHSWSTGEEVAGDILRHRGLADGWRGWTVAMK 2270
            :.:|:.|:                 |||....|:|..:|   |...::|:        |..:...
Yeast  1107 LLMDLNCYTLEVTEGYLKKVNVTEVNGDNVLGPIHVITT---VVSSLVRN--------GLLIQSS 1160

Human  2271 NGVQWAELAGHDYVLDLVSDLELL 2294
            ..:....|.....|:.|..|..:|
Yeast  1161 KFISKVLLTVESIVMSLPKDETML 1184

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO15A	XP_016880204.1	None
MYO4	NP_009373.1	COG5022	2..1471	CDD:227355	372/1259 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810