DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EGFL7 and Y64G10A.7

DIOPT Version :9

Sequence 1:	NP_057299.1	Gene:	EGFL7 / 51162	HGNCID:	20594	Length:	273	Species:	Homo sapiens
Sequence 2:	NP_001255802.1	Gene:	Y64G10A.7 / 178377	WormBaseID:	WBGene00013416	Length:	1714	Species:	Caenorhabditis elegans

Alignment Length:	195	Identity:	69/195 - (35%)
Similarity:	88/195 - (45%)	Gaps:	42/195 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    28 RRVCAVRAHGD----PVSESFVQRVYQPFLTT----CDG-HRACSTY--RTIYRTAYRRSPGLAP 81
            |.||   .|.:    .:.|..|| .|..::.:    |:| .::|:..  :|||...|::     .
Worm    34 RNVC---PHEEVEIVTLKEPCVQ-AYTKYVRSRKPGCNGKFQSCAVRQPKTIYFHTYKK-----V 89

Human    82 ARPR----YACCPGWKRTSGLPGACGAAICQPP-CRNGGSCVQPGR-------CRCPAGWRGDTC 134
            .|.|    ..|||||....|..| |..|.|... |.|||:|| |..       |.||.|:.|..|
Worm    90 NRTRRHTVAECCPGWVHRPGEAG-CQRANCSADLCHNGGTCV-PSEHNDNEQVCECPVGFTGAKC 152

Human   135 QSDVDECSARRGGCPQRCVNTAGSYWCQCWEGHSLSADGTLC-------VPKGG-PPRVAPNPTG 191
            |.|.:||.|..|||...||||.|:|:|:||.|..||.||..|       |..|| ..|...:|.|
Worm   153 QYDANECMANNGGCEHECVNTIGTYYCRCWPGFELSGDGNTCSDIDECAVSNGGCSDRCVNSPGG 217

Human 192 191
Worm 218 217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EGFL7	NP_057299.1	EMI	29..93	CDD:369419	20/78 (26%)
		EGF_CA	<110..135	CDD:238011	12/32 (38%)
		Cell attachment site	130..132		0/1 (0%)
		FXa_inhibition	141..176	CDD:373209	19/34 (56%)
Y64G10A.7	NP_001255802.1	EMI	35..105	CDD:284877	20/78 (26%)
		FXa_inhibition	159..194	CDD:291342	19/34 (56%)
		FXa_inhibition	200..235	CDD:291342	6/18 (33%)
		FXa_inhibition	241..278	CDD:291342
		vWFA	<319..358	CDD:294047
		FXa_inhibition	366..402	CDD:291342
		vWFA	<460..502	CDD:294047
		FXa_inhibition	509..544	CDD:291342
		FXa_inhibition	550..585	CDD:291342
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001719
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910