Protein Alignment DYNC1LI1 and Dlic

DIOPT Version :10

• Sequence 1: NP_057225.2
• Gene: DYNC1LI1 / 51143
• HGNCID: 18745
• Length: 523
• Species: Homo sapiens
• Sequence 2: NP_572694.1
• Gene: Dlic / 32057
• FlyBaseID: FBgn0030276
• Length: 493
• Species: Drosophila melanogaster
• Alignment Length: 516
• Identity: 237/516 - (45%)
• Similarity: 317/516 - (61%)
• Gaps: 63/516 - (12%)

Human    11 GSSPPGLSSTYTGGPLGNEIASGNGGAAAGDDEDGQNLWSCILSEVSTRSRSKLPAGKNVLLLGE 75
            |:....|:|::|         .....|||    :.:||||.||:||.|:..:|||:.|:||:||:
  Fly     6 GTQTNALTSSFT---------MKKKDAAA----EKENLWSAILNEVQTQGSTKLPSNKSVLVLGD 57

Human    76 DGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVS 140
            :..|||:||.|:||:|:.|||.||||.|::|.||.|||.||..||:||||..|..||.::|:..:
  Fly    58 NATGKTTLIAKLQGVEDPKKGSGLEYAYIDVKDEYRDDMTRLGVWVLDGDPGHTNLLHYALNETN 122

Human   141 LKDTLVMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDF- 204
            ...|||:|.|.|::||..|:.|..|..|:.:|:|.|::..:|.:...|:|...:|.|.|.|:|.
  Fly   123 YAHTLVILTVSMTQPWGWLEQLNHWIKVLGQHIDSLQLDAKEKEAARQRLTTTWQSYCEVGDDLD 187

Human   205 PASPQRRNTASQE-DKDDSVVLPLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFIQ 268
            |.||.:|...:.. |:||  :|||..|.|..|||:.::||.||.|.::.||||::||||||||||
  Fly   188 PGSPVKRTMRNNSIDEDD--LLPLTEDALITNLGLDIVVVVTKTDYMTTLEKEYEYRDEHFDFIQ 250

Human   269 SHIRKFCLQYGAALIYTSVKENKNIDLVYKYIVQKLYGFPYKIPAVVVEKDAVFIPAGWDNDKKI 333
            ..||.|||::|.:|.||||||:||.|::|||:..::||.|::.||:|||||||.||||||:.|||
  Fly   251 QWIRNFCLRHGTSLFYTSVKEDKNCDVLYKYLTHRIYGLPFRTPALVVEKDAVLIPAGWDSLKKI 315

Human   334 GILHENFQTLKAEDNFEDIITKPPVRKFV--HEKEIMAEDDQVFLMKLQSLLAKQPPTAAGRPVD 396
            .||:||...:|||:.:.|||..||.||.|  .|.|:..||:|.||.:.|.:| ||.....|.
  Fly   316 SILYENMHGVKAENPYTDIIKSPPTRKAVSNREAEVQTEDEQAFLARQQEIL-KQGDQVRGE--- 376

Human   397 ASP-RVPG-GS----PRTPNRSVSSNVASVSPIPAGSKKIDPNM-KAGATSEGVLANFFNSLLSK 454
             || |..| ||    ||||..:..|     ||     |||||.: .|...:||||||||||||.|
  Fly   377 -SPLRSQGVGSNKSGPRTPGTTGQS-----SP-----KKIDPKLTPATPGAEGVLANFFNSLLHK 430

Human   455 KTGSP--GGPGVSGGSPAGGAGGGSSGLPPSTKKSGQKPVL---------DVHAELDRITR 504
            |:|||  |||| ..|:|||          |....:|...|:         |..|||||::|
  Fly   431 KSGSPGTGGPG-GAGNPAG----------PGRTANGTDAVMTPEKLAVRTDAAAELDRLSR 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DYNC1LI1	NP_057225.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		4/13 (31%)
		DLIC	43..517	CDD:368612	230/484 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	387..434		19/52 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	456..523		21/60 (35%)
Dlic	NP_572694.1	DLIC	25..489	CDD:368612	231/488 (47%)