DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment COQ4 and Coq4

DIOPT Version :9

Sequence 1:	NP_057119.3	Gene:	COQ4 / 51117	HGNCID:	19693	Length:	265	Species:	Homo sapiens
Sequence 2:	NP_001246815.1	Gene:	Coq4 / 261607	FlyBaseID:	FBgn0052174	Length:	268	Species:	Drosophila melanogaster

Alignment Length:	258	Identity:	118/258 - (45%)
Similarity:	165/258 - (63%)	Gaps:	8/258 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     4 LLRPV-LRRLCGL----PGLQRPAAEMPLRARSDGAGPLY-SHHLPTSPLQKGLLAAGSAAMALY 62
            |.:|: |||  ||    ...|..|.|.|.....|.....| ...:..||.|:..|.|||:..||.
  Fly     8 LQKPLALRR--GLRLAQANSQAVATEAPEAEPLDAFERQYLKERIEISPFQRLFLGAGSSIAALL 70

Human    63 NPYRHDMVAVLGETTGHRTLKVLRDQMRRDPEGAQILQERPRISTSTLDLGKLQSLPEGSLGREY 127
            ||.||||:|.||||||...|..:.|.|:...||.:|:.::|||.|||:|...|::||..:.|..|
  Fly    71 NPRRHDMIACLGETTGEDALWTILDTMQASEEGQRIMADKPRIHTSTIDFKYLETLPPDTFGAAY 135

Human   128 LRFLDVNRVSPDTRAPTRFVDDEELAYVIQRYREVHDMLHTLLGMPTNILGEIVVKWFEAVQTGL 192
            ::||..|:|:||:|...||::|.:|||::.||||.||::||:|.||||:|||:.|||.||:.|||
  Fly   136 VKFLKDNQVTPDSRMAVRFLEDPKLAYLMTRYRECHDLIHTVLDMPTNMLGEVAVKWVEALNTGL 200

Human   193 PMCILGAFFGPIRLGAQSLQVLVSELIPWAVQNGRRAPCVLNLYYERRWEQSLRALREELGIT 255
            |||..||.||.:||..:..:..:...:|||::||:|...::.:|:|:||||::..||.|||||
  Fly   201 PMCYGGAVFGAVRLRPKQRRAYLKHYLPWALENGKRTKPLMPVYWEKRWEQNIHELRSELGIT 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COQ4	NP_057119.3	Coq4	46..258	CDD:309936	104/210 (50%)
Coq4	NP_001246815.1	Coq4	54..265	CDD:282826	104/210 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152779
Domainoid	1	1.000	228	1.000	Domainoid score	I2504
eggNOG	1	0.900	-	-		E1_COG5031
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68641
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3481
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54901
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004197
OrthoInspector	1	1.000	-	-		oto89919
orthoMCL	1	0.900	-	-		OOG6_103250
Panther	1	1.100	-	-	LDO	PTHR12922
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R234
SonicParanoid	1	1.000	-	-		X2942
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790