DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZDHHC9 and Hip14

DIOPT Version :9

Sequence 1:	NP_001008223.1	Gene:	ZDHHC9 / 51114	HGNCID:	18475	Length:	364	Species:	Homo sapiens
Sequence 2:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	281	Identity:	79/281 - (28%)
Similarity:	126/281 - (44%)	Gaps:	52/281 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    40 LTLFLILGTCTLFFAFECRYLAVQLSPAIPVFAAMLFLFSMATL----LRTSFSDPGVIPRALPD 100
            |.|.:.|.|...|:.....|    :..|:...|.:.||.|...|    |::...|||:| |...:
  Fly   350 LPLSVYLATKAWFYVTWLMY----IDDAVSFTATVCFLISSLLLWVCFLKSWKGDPGII-RPTRE 409

Human   101 EAAFIEMEIEATNGAVPQGQRPPPRIKNFQINNQIVKLKYCYTCKIFRPPRASHCSICDNCVERF 165
            :.....:|:....|.   |..|               ..:|..|.:.||.|:.|||:||.||.||
  Fly   410 QRFKTIIELSERGGI---GFEP---------------ASFCSGCLVRRPIRSKHCSVCDRCVARF 456

Human   166 DHHCPWVGNCVGKRNYRYFYLFILSLSLLTIY-VFAFNIVYVALKSLKI-GFLETLKET------ 222
            ||||||||||:|.:|:.||..|:..|.::..: ::..:..||...:::. .||..::..
  Fly   457 DHHCPWVGNCIGLKNHSYFMGFLWMLLIMCAWMLYGGSKYYVNQCNVRFDDFLGAMRAIGNCDAW 521

Human   223 PGTVLEVLICFFTLWSVVGLTGFHTF-LVALNQTTNEDIKGSWTGKNR------VQNPYSHG--- 277
            .|.|:...:...: | |:.||...|: ::.|..||||.:.   .|:.|      ..:|::.|
  Fly   522 VGWVMGNALLHMS-W-VILLTICQTYQVICLGMTTNERMN---RGRYRHFQAKGGHSPFTRGPIQ 581

Human   278 NIVKNCCEVLC-GPLPPSVLD 297
            |:| :..|..| |.:.|..:|
  Fly   582 NLV-DFLECSCFGLVQPKRVD 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZDHHC9	NP_001008223.1	DHHC	138..261	CDD:396215	46/131 (35%)
ZDHHC9	NP_001008223.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	303..364
Hip14	NP_001261910.1	ANK	52..165	CDD:238125
		Ank_2	52..142	CDD:289560
		ANK repeat	77..108	CDD:293786
		ANK repeat	110..142	CDD:293786
		ANK	114..233	CDD:238125
		Ank_2	116..209	CDD:289560
		ANK repeat	144..175	CDD:293786
		ANK repeat	177..209	CDD:293786
		Ank_5	198..251	CDD:290568
		ANK repeat	212..244	CDD:293786
		zf-DHHC	426..559	CDD:279823	47/149 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810