DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZDHHC9 and Zdhhc8

DIOPT Version :9

Sequence 1:	NP_001008223.1	Gene:	ZDHHC9 / 51114	HGNCID:	18475	Length:	364	Species:	Homo sapiens
Sequence 2:	NP_001259382.1	Gene:	Zdhhc8 / 31887	FlyBaseID:	FBgn0085478	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	281	Identity:	108/281 - (38%)
Similarity:	161/281 - (57%)	Gaps:	33/281 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    44 LILGTCTLFFAFECRYLAVQLSPAIPVFAAMLFLFSMATLLRTSFSDPGVIPRALPDEAAFIEME 108
            ::|.|..|||.:.|::. |:..|.:..:..::..|.:|.....:|.|||:||:|.|||..  |.|
  Fly    19 VLLLTTFLFFFYPCQFY-VKSHPWVLAYQGVITFFVLANFTLATFMDPGIIPKASPDEDC--EEE 80

Human   109 IEATNGAVPQGQRPPPRIKNFQINNQIVKLKYCYTCKIFRPPRASHCSICDNCVERFDHHCPWVG 173
            :.|            |..||.:||...||:|:|.|||.:||||.||||:|::|:|.||||||||.
  Fly    81 LRA------------PLYKNAEINGITVKMKWCVTCKFYRPPRCSHCSVCNHCIETFDHHCPWVN 133

Human   174 NCVGKRNYRYFYLFILSLSLLTIYVFAFNIVYVALKSLKIGFLETLKETPGTVLEVLICFFTLWS 238
            ||:|:||||:|:.|::|||:..:.:|:..:|||    |||  :..:|:|...|..:|:...|:.:
  Fly   134 NCIGRRNYRFFFFFLVSLSIHMLSIFSLCLVYV----LKI--MPNIKDTAPIVAIILMGLVTILA 192

Human   239 --VVGLTGFHTFLVALNQTTNEDIKGSWTGKNRVQNPYSHGNIVKNCCEVLCGPLPPSVLDRRGI 301
              :.||||||..||:..:||||.:.|.:.|.   .||:|.| ...|||....||..||:|:.:
  Fly   193 IPIFGLTGFHMVLVSRGRTTNEQVTGKFKGG---YNPFSRG-CWHNCCYTQFGPQYPSLLNPK-- 251

Human   302 LPLEESGSRPPSTQETSSSLL 322
                :..||....|..:.|.:
  Fly   252 ----KYASRRSQVQNQAISTI 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZDHHC9	NP_001008223.1	DHHC	138..261	CDD:396215	60/124 (48%)
ZDHHC9	NP_001008223.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	303..364		4/20 (20%)
Zdhhc8	NP_001259382.1	zf-DHHC	94..219	CDD:279823	62/130 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1264614at2759
OrthoFinder	1	1.000	-	-		FOG0000285
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R405
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850