Protein Alignment MECR and Drat

DIOPT Version :10

• Sequence 1: XP_011539841.1
• Gene: MECR / 51102
• HGNCID: 19691
• Length: 459
• Species: Homo sapiens
• Sequence 2: NP_610293.3
• Gene: Drat / 35687
• FlyBaseID: FBgn0033188
• Length: 434
• Species: Drosophila melanogaster
• Alignment Length: 344
• Identity: 71/344 - (20%)
• Similarity: 125/344 - (36%)
• Gaps: 118/344 - (34%)

Human    81 ISSASTVLKNLELAAVRGSDV--RVKMLAAPINPSDINMIQG--NYGFLPELPAVGGNEGVAQVV 141
            |:|.|:|...|       ||.  .|..:::|.:       ||  ...|.|      |.|....:.
  Fly   109 ITSMSSVSSEL-------SDYCPSVNSMSSPAH-------QGIREGSFFP------GFEVAGVIE 153

Human   142 AVGSNVT-----GLKPGDWVI--PANAGLGTWRTEAVFSE-------EALIQVPSDIPLQSAATL 192
            ::||.:|     ||:.|..||  |.:      .|.|.::|       :.::.:|..:|::.||.|
  Fly   154 SLGSEITEANNRGLRIGQRVIVYPFD------ETPAGYAELLVVPDLKHVVPIPDSLPMEVAAML 212

Human   193 GVNPCTAYRMLMDFEQL---------------QPGDSVIQNASNSGVGQAVIQIA----AALGLR 238
            ......|:..:...:.:               :|...::   ...|:....::||    |..|..
  Fly   213 PTGALLAWNAVFKAQAVVTQILSQRAATEPKRKPKILIV---GTGGLALWAVRIASYHFATTGAD 274

Human   239 TINV----VRDR-----PDIQKLS--------------DRLKSL--GAEHVI-----TEEELRRP 273
            .:::    :||.     .:|:.:|              :|.|.:  ||..|:     |...|.|
  Fly   275 NVDITVASLRDEGFRLATEIKNVSVVQWNECLYEPQLIERTKDVCGGAVDVVIDFGTTSRSLHR- 338

Human   274 EMKNFFK---------IRKLRLRKEEMLNQNH-----IVYKGSRE--SELASVSPNSKPLNLPEP 322
            .|....|         :.:..|.|...|::.:     .:..|:.|  :||..:..|.|    .||
  Fly   339 SMHCLSKGGVVLISDEVAEKLLPKFSRLSEQYQQEIIAISNGTAEQLAELVELVANKK----IEP 399

Human   323 PPHNM-PRHAPATACSQLC 340
            |||:: |....|...::||
  Fly   400 PPHSVFPCEQAAEVIAKLC 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MECR	XP_011539841.1	ETR	44..459	CDD:176250	71/344 (21%)
Drat	NP_610293.3	MDR	144..428	CDD:450120	59/295 (20%)