DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MECR and Mecr

DIOPT Version :10

Sequence 1:XP_011539841.1 Gene:MECR / 51102 HGNCID:19691 Length:459 Species:Homo sapiens
Sequence 2:XP_063143330.1 Gene:Mecr / 29470 RGDID:3208 Length:408 Species:Rattus norvegicus


Alignment Length:480 Identity:280/480 - (58%)
Similarity:320/480 - (66%) Gaps:93/480 - (19%)


- Green bases have known domain annotations that are detailed below.


Human     1 MWVCSTLWRVRTPARQWRGLLPASGCHGPAASSYSASAEPARVRALVYGHHGDPAKVVEG----- 60
            |.|...|...|..|.....||.|....|...|||||.:||:.|||||||:|||||||:..     
  Rat     1 MLVSRRLTGARARAPLLASLLEAWCRQGRTTSSYSAFSEPSHVRALVYGNHGDPAKVIHSGVPGT 65

Human    61 -------ITRELFQRFPWIFLQLITAVISSASTVLK-----NLELAAVRGSDVRVKMLAAPINPS 113
                   ::.|.::..|          .:|..|::.     ||||.||.||||.|||||||||||
  Rat    66 GLYECCYMSAEDWKSGP----------CASQKTLIAARRDINLELTAVEGSDVHVKMLAAPINPS 120

Human   114 DINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALI 178
            ||||||||||.||:||||||||||.||:||||:|:||||||||||||||||||||||||||||||
  Rat   121 DINMIQGNYGLLPKLPAVGGNEGVGQVIAVGSSVSGLKPGDWVIPANAGLGTWRTEAVFSEEALI 185

Human   179 QVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVV 243
            .||.|||||||||||||||||||||:||||||||||||||||||||||||||||:||||:||||:
  Rat   186 GVPKDIPLQSAATLGVNPCTAYRMLVDFEQLQPGDSVIQNASNSGVGQAVIQIASALGLKTINVI 250

Human   244 RDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFK---IRKLRLRKEEMLNQNHIVYKGSRES 305
            ||||||:||:||||.|||::|:||||||.||.||.||   :.:|.|        |.:..|.|.| 
  Rat   251 RDRPDIKKLTDRLKDLGADYVLTEEELRMPETKNIFKDLPLPRLAL--------NCVGGKSSTE- 306

Human   306 ELASVSPNSKPLNLPEPPPHNMPRH-APATACSQLCWWEKLHRAAAAVSAWRNHGNLWGDGQAAR 369
                                 :.|| ||.                         |.:...|..|:
  Rat   307 ---------------------LLRHLAPG-------------------------GTMVTYGGMAK 325

Human   370 RSLCEPSMSFLCLQSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQV 434
                :|..:.:   |:||||||||||||||||||:||||:||||||.||:|||:|||||||.|.:
  Rat   326 ----QPVTASV---SMLIFKDLKLRGFWLSQWKKNHSPDEFKELILFLCNLIRQGQLTAPAWSGI 383

Human   435 PLQDYQSALEASMKPFISSKQILTM 459
            ||||||.|||||||||:||||||||
  Rat   384 PLQDYQQALEASMKPFVSSKQILTM 408

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MECRXP_011539841.1 ETR 44..459 CDD:176250 261/435 (60%)
MecrXP_063143330.1 None

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