Protein Alignment SEPSECS and SecS

DIOPT Version :10

• Sequence 1: NP_001397643.1
• Gene: SEPSECS / 51091
• HGNCID: 30605
• Length: 586
• Species: Homo sapiens
• Sequence 2: NP_649556.3
• Gene: SecS / 40681
• FlyBaseID: FBgn0037347
• Length: 478
• Species: Drosophila melanogaster
• Alignment Length: 553
• Identity: 221/553 - (39%)
• Similarity: 319/553 - (57%)
• Gaps: 85/553 - (15%)

Human     1 MNRESFAAGERLVSPAYVRQGCEARRSHEHLIRLLLEKSLALSPRLECSVTISAHCSLRLPGSRH 65
            ||.|.....|:||...|::.|..|:||.:...:.||||.
  Fly     1 MNFEQVNIPEKLVPDNYLQLGLAAQRSKQRSFKELLEKR-------------------------- 39

Human    66 SPASASRVAGTTGARHHTRLMFVFLVEMGFHHVGQADLKLLTSSDRPFLAFQSARITGGKCPENG 130
                                                                       |.|:||
  Fly    40 -----------------------------------------------------------KLPKNG 45

Human   131 WDESTLELFLHELAIMDSNNFLGNCGVGEREGRVASALVARRHYRFIHGIGRSGDISAVQPKAAG 195
            |.:..:|..:|.||.:||||:....|:||||.|:|..|||||||.|.||||||||:...||||||
  Fly    46 WSDERIEELVHMLASLDSNNYPHKVGLGEREARIACKLVARRHYNFGHGIGRSGDLLEAQPKAAG 110

Human   196 SSLLNKITNSLVLDIIKLAGVHTVANCFVVPMATGMSLTLCFLTLRHKRPKAKYIIWPRIDQKSC 260
            |:||.::||:|:||:|:..|:.:.|.||:|||.|||:||||..:||.:||.|:|::|.|||||||
  Fly   111 STLLARLTNALILDLIRGIGLPSCAGCFLVPMCTGMTLTLCLQSLRKRRPGARYVLWSRIDQKSC 175

Human   261 FKSMITAGFEPVVIENVLEGDELRTDLKAVEAKVQELGPDCILCIHSTTSCFAPRVPDRLEELAV 325
            ||::...|..||||..:::|:.|.|::.....|::.||.|.|||:::||||||||..|.:.|::.
  Fly   176 FKAITATGLVPVVIPCLIKGESLNTNVDLFREKIKSLGVDSILCLYTTTSCFAPRNSDDIAEVSK 240

Human   326 ICANYDIPHIVNNAYGVQSSKCMHLIQQGARVGRIDAFVQSLDKNFMVPVGGAIIAGFNDSFIQE 390
            :...:.|||:||||||:|:.:.::.::...||||||.||||.|||.:||||.||:|.||:|.:.:
  Fly   241 LSKQWQIPHLVNNAYGLQAKEIVNQLECANRVGRIDYFVQSSDKNLLVPVGSAIVASFNESVLHD 305

Human   391 ISKMYPGRASASPSLDVLITLLSLGSNGYKKLLKERKEMFSYLSNQIKKLSEAYNERLLHTPHNP 455
            ::..|.||||.|.|||||:||||||.||::.|..:|.|.|:||...::|.:|...|.::.:..|.
  Fly   306 VASTYAGRASGSQSLDVLMTLLSLGRNGFRLLFDQRGENFNYLRENLRKFAEPRGEIVIDSRFNS 370

Human   456 ISLAMTLKTLDEHRDKAVTQLGSMLFTRQVSGARVVPLGSMQTVSGYTFRGFMSHTNNYPCAYLN 520
            ||||:||.||...:.|::|:|||||..|.||||||:..|..:|:.|:.|..|.||.:|....||.
  Fly   371 ISLAITLATLAGDQMKSITKLGSMLHMRGVSGARVIVPGQNKTIDGHEFLDFGSHRSNLQVPYLT 435

Human   521 AASAIGMKMQDVDLFIKRLDRCLKAVRKERSKE 553
            .|:.||:..:::|.|....::|...:.:.::::
  Fly   436 VAAGIGITREEIDKFFDIFNKCWNQIFQTKNEK 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SEPSECS	NP_001397643.1	selenium_SpcS	12..543	CDD:211833	216/530 (41%)
SecS	NP_649556.3	AAT_I	12..457	CDD:450240	216/529 (41%)