Protein Alignment SEPSECS and Tdc1

DIOPT Version :10

• Sequence 1: NP_001397643.1
• Gene: SEPSECS / 51091
• HGNCID: 30605
• Length: 586
• Species: Homo sapiens
• Sequence 2: NP_610226.2
• Gene: Tdc1 / 35573
• FlyBaseID: FBgn0259977
• Length: 587
• Species: Drosophila melanogaster
• Alignment Length: 515
• Identity: 104/515 - (20%)
• Similarity: 169/515 - (32%)
• Gaps: 182/515 - (35%)

Human    31 LIRLLLEKSLALSPRLECSVTISAHCSLRLP-----GSRHSPASASRVAGTTGARHHTRLMFVFL 90
            |:.|:..::.|:|   |.....|.|.|:.||     .||.:.:|..:.         |::..|.|
  Fly   154 LVSLITARARAIS---ELKGQTSVHDSVFLPSLIAYASREAHSSVEKA---------TKMALVKL 206

Human    91 VEMGFHHVGQADLKLLTSSDR--------PFLAFQSARITGGKCPENGWDEST---------LEL 138
            ..:.....|:..:.||..:.:        ||....:...||| |   .:|:.|         ..:
  Fly   207 RIIDADEHGRMRVDLLRQAIQNDVNAGLTPFFVVATVGTTGG-C---AFDDITEIGKVCRQVSSI 267

Human   139 FLHELAIMDSNNFLGNCGVGEREGRVASALVARRHYRFIHGIGRSG--------------DISA- 188
            :||.......|:|:      ..|.||.||           |:..:.              |.||
  Fly   268 WLHVDGAYAGNSFI------LPEMRVFSA-----------GLEYADSFNTNPNKLLLTNFDASAL 315

Human   189 -VQPKAAGSSLLNKITNSLVLDIIKLAGV---HTVANCFVVPMA---TGMSLTLCFLT------- 239
             |:......|.||  .|.|.|....|.||   |     :.:|::   ..:.|...|.|
  Fly   316 WVRDVMNLKSALN--VNPLYLRHEHLTGVDYRH-----YGIPLSRRFRALKLWFVFRTYGIRGLQ 373

Human   240 --LRHKRPKAKYIIWPRIDQKSCFKSMITAGFEPVVIENVLEGDELRTDLKAVEAKVQELGPDCI 302
              :|:....||                   .||.:|.::  |..|:|.|
  Fly   374 EYIRNHMALAK-------------------KFEMLVRKD--ERFEVRND---------------- 401

Human   303 LCIHSTTSCFAPRVPDRLEELAVICANYD-----IPHIVNNAYGVQSSKCM---HLIQQGARVGR 359
              :|....||..|..|....:.:...|:.     .|...|..|.::.  |:   |..::..
  Fly   402 --VHLGLVCFRMRTGDEPNHMLLAQINHSGKMHMTPAKFNGRYVIRF--CVTYEHATEKDI---- 458

Human   360 IDAFVQSLDKNFMVPVGGAIIAGFNDSFIQE---ISKMYP------GRASASPSLDVLITLLSLG 415
            ::|:.|              |..|.:..:::   .|...|      .|.|:.|...|      .|
  Fly   459 LEAWTQ--------------IKCFAEEILRDHQLESSSVPTTPEGSERTSSEPLAPV------AG 503

Human   416 SNGYKKLLKERKEM-FSYLSNQIKKLSEAYNERLLH--TPHNPISLAMTLKTLDEHRDKA 472
            ....||.|...|.: ||:..:..::..::.:|.|:.  ||    .|.:..|||.|:..||
  Fly   504 KPPIKKRLTRTKSLRFSFTRSISREQYQSQSEHLMDGCTP----ILVVDPKTLQENFQKA 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SEPSECS	NP_001397643.1	selenium_SpcS	12..543	CDD:211833	104/515 (20%)
Tdc1	NP_610226.2	Pyridoxal_deC	35..412	CDD:395219	68/336 (20%)